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Full-Text Articles in Life Sciences
Phylogenetic Diversification Of The Globin Gene Superfamily In Chordates, Jay F. Storz, Juan C. Opazo, Federico G. Hoffmann
Phylogenetic Diversification Of The Globin Gene Superfamily In Chordates, Jay F. Storz, Juan C. Opazo, Federico G. Hoffmann
Jay F. Storz Publications
Phylogenetic reconstructions provide a means of inferring the branching relationships among members of multigene families that have diversified via successive rounds of gene duplication and divergence. Such reconstructions can illuminate the pathways by which particular expression patterns and protein functions evolved. For example, phylogenetic analyses can reveal cases in which similar expression patterns or functional properties evolved independently in different lineages, either through convergence, parallelism, or evolutionary reversals. The purpose of this article is to provide a robust phylogenetic framework for interpreting experimental data and for generating hypotheses about the functional evolution of globin proteins in chordate animals. To do …
Differential Loss And Retention Of Cytoglobin, Myoglobin, And Globin-E During The Radiation Of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz
Differential Loss And Retention Of Cytoglobin, Myoglobin, And Globin-E During The Radiation Of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz
Jay F. Storz Publications
If rates of postduplication gene retention are positively correlated with levels of functional constraint, then gene duplicates that have been retained in a restricted number of taxonomic lineages would be expected to exhibit relatively low levels of sequence conservation. Paradoxical patterns are presented by gene duplicates that have been retained in a small number of taxa but which are nonetheless subject to strong purifying selection relative to paralogous members of the same multigene family. This pattern suggests that such genes may have been co-opted for novel, lineage-specific functions. One possible example involves the enigmatic globin-E gene (GbE), which …
Lineage-Specific Patterns Of Functional Diversification In The Α- And Β-Globin Gene Families Of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz, Thomas A. Gorr, Juan C. Opazo
Lineage-Specific Patterns Of Functional Diversification In The Α- And Β-Globin Gene Families Of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz, Thomas A. Gorr, Juan C. Opazo
Jay F. Storz Publications
The α- and β-globin gene families of jawed vertebrates have diversified with respect to both gene function and the developmental timing of gene expression. Phylogenetic reconstructions of globin gene family evolution have provided suggestive evidence that the developmental regulation of hemoglobin synthesis has evolved independently in multiple vertebrate lineages. For example, the embryonic β-like globin genes of birds and placental mammals are not 1:1 orthologs. Despite the similarity in developmental expression profiles, the genes are independently derived from lineage-specific duplications of a β-globin pro-ortholog. This suggests the possibility that other vertebrate taxa may also possess distinct repertoires of globin genes …
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Jay F. Storz Publications
The functional diversification of multigene families may be strongly influenced by mechanisms of concerted evolution such as interparalog gene conversion. The β-globin gene family of house mice (genus Mus) represents an especially promising system for evaluating the effects of gene conversion on the functional divergence of duplicated genes. Whereas the majority of mammalian species possess tandemly duplicated copies of the adult β-globin gene that are identical in sequence, natural populations of house mice are often polymorphic for distinct two-locus haplotypes that differ in levels of functional divergence between duplicated β-globin genes, HBB-T1 and HBB-T2. Here, we use a phylogenetic …
Origin And Ascendancy Of A Chimeric Fusion Gene: The Β/Δ-Globin Gene Of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, Jay F. Storz
Origin And Ascendancy Of A Chimeric Fusion Gene: The Β/Δ-Globin Gene Of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, Jay F. Storz
Jay F. Storz Publications
The δ-globin gene (HBD) of eutherian mammals exhibits a propensity for recombinational exchange with the closely linked β-globin gene (HBB) and has been independently converted by the HBB gene in multiple lineages. Here we report the presence of a chimeric β/δ fusion gene in the African elephant (Loxodonta africana) that was created by unequal crossing-over between misaligned HBD and HBB paralogs. The recombinant chromosome that harbors the β/δ fusion gene in elephants is structurally similar to the ‘‘anti-Lepore’’ duplication mutant of humans (the reciprocal exchange product of the hemoglobin Lepore deletion mutant). However, the situation in …
Genomic Evidence For Independent Origins Of Β-Like Globin Genes In Monotremes And Therian Mammals, Juan C. Opazo, Federico G. Hoffmann, Jay F. Storz
Genomic Evidence For Independent Origins Of Β-Like Globin Genes In Monotremes And Therian Mammals, Juan C. Opazo, Federico G. Hoffmann, Jay F. Storz
Jay F. Storz Publications
Phylogenetic reconstructions of the β-globin gene family in vertebrates have revealed that developmentally regulated systems of hemoglobin synthesis have been reinvented multiple times in independent lineages. For example, the functional differentiation of embryonic and adult β-like globin genes occurred independently in birds and mammals. In both taxa, the embryonic β-globin gene is exclusively expressed in primitive erythroid cells derived from the yolk sac. However, the “ε-globin” gene in birds is not orthologous to the ε-globin gene in mammals, because they are independently derived from lineage-specific duplications of a proto β-globin gene. Here, we report evidence that the early and late …
The ΑD-Globin Gene Originated Via Duplication Of An Embryonic Α-Like Globin Gene In The Ancestor Of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz
The ΑD-Globin Gene Originated Via Duplication Of An Embryonic Α-Like Globin Gene In The Ancestor Of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz
Jay F. Storz Publications
Gene duplication is thought to play an important role in the co-option of existing protein functions to new physiological pathways. The globin superfamily of genes provides an excellent example of the kind of physiological versatility that can be attained through the functional and regulatory divergence of duplicated genes that encode different subunit polypeptides of the tetrameric hemoglobin protein. In contrast to prevailing views about the evolutionary history of the α-globin gene family, here we present phylogenetic evidence that the αA- and αD-globin genes are not the product of a single, tandem duplication of an ancestral globin …