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Wayne State University Dissertations
Aedes aegypti, Dengue, mosquito, Protein-protein interaction, yeast two-hybrid
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Characterization Of Intracellular Interactions Between Dengue Virus And Host Proteins, Dumrong Mairiang
Characterization Of Intracellular Interactions Between Dengue Virus And Host Proteins, Dumrong Mairiang
Wayne State University Dissertations
Dengue virus is the causative agent of dengue fever, dengue hemorrhagic fever and dengue shock syndrome. About two-fifths of world population live in areas where dengue is prevalent, leading to high levels of morbidity and mortality in many areas. Currently there are no vaccines or effective treatments. The virus is transmitted from one person to another by the yellow fever mosquito, Aedes aegypti. The genome of dengue virus encodes only ten proteins implying that the virus needs to interact with and utilize several host proteins for replication. In this project, I used high-throughput yeast two-hybrid screening to identify mosquito and …