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An Interaction Between Centrosome Scaffold Proteins And A Retrotransposon Nucleocapsid Protein May Alter Asymmetric Centrosome Inheritance, Lanilei Doctora
An Interaction Between Centrosome Scaffold Proteins And A Retrotransposon Nucleocapsid Protein May Alter Asymmetric Centrosome Inheritance, Lanilei Doctora
Legacy Theses & Dissertations (2009 - 2024)
Nearly all eukaryotic genomes harbor mobile genetic elements known as retrotransposons. The mRNA ofthese elements undergo reverse transcription, yielding cDNA that is inserted in a new location in the host genome. We study Saccharomyces cerevisiae Ty1 elements, an active family of retrovirus-like retrotransposons, and the mechanism behind its regulation of spindle pole body (SPB) inheritance. Ty1 retromobility is activated during growth at 20˚C. In a manuscript that includes my work (Murphy et al., 2022, manuscript in preparation), we report that essential SPB proteins Nud1 and Spc42 are sequestered in the Ty1 retrosome, the site of Ty1 nucleocapsid assembly, in a …