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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Genetic Structure Of Urban White-Tailed Deer In West Michigan, Jacob David Brand
Genetic Structure Of Urban White-Tailed Deer In West Michigan, Jacob David Brand
Masters Theses
In urban areas, green spaces are used by humans and wildlife. The proximity between them can lead to both positive and negative interactions, which can make managing urban wildlife difficult. Managers are challenged due to conflicts between wildlife population sizes that can be naturally supported versus those that are socially tolerable. White-tailed deer (Odocoileus virginianus) thrive in urban environments because their habitat requirements are met within green spaces and backyard vegetation. Matrilineal groups of urban white-tailed deer live within the same areas, at times forming high densities that can lead to the spread of diseases or environmental pests, including hemlock …
Pedigree And Molecular Assessment Of Relatedness In A Captive Chimpanzee Population, Francesca Golus
Pedigree And Molecular Assessment Of Relatedness In A Captive Chimpanzee Population, Francesca Golus
Masters Theses
As a crucial component of biodiversity, genetic diversity contributes to variability among individuals, allowing populations of endangered species to be resilient in the face of changing environmental conditions. Zoological institutions have become a cornerstone of conservation efforts and a refuge for endangered species given threats imposed on wild populations by climate change, habitat fragmentation and degradation, and overexploitation. Chimpanzees (Pan troglodytes) are an endangered species experiencing drastic population decline in the wild, yet are common residents in zoos and wildlife sanctuaries. To sustain long-term, genetically viable populations of species of concern, zoos use studbooks and paternity testing to …
Nemo-Like Kinase (Nlk) Is A Pathological Signaling Effector In The Mouse Heart, Ruijie Liu
Nemo-Like Kinase (Nlk) Is A Pathological Signaling Effector In The Mouse Heart, Ruijie Liu
Peer Reviewed Articles
Nemo-like kinase (NLK) is an evolutionary conserved serine/threonine protein kinase implicated in development, proliferation and apoptosis regulation. Here we identified NLK as a gene product induced in the hearts of mice subjected to pressure overload or myocardial infarction injury, suggesting a potential regulatory role with pathological stimulation to this organ. To examine the potential functional consequences of increased NLK levels, cardiac-specific transgenic mice with inducible expression of this gene product were generated, as well as cardiac-specific Nlk gene-deleted mice. NLK transgenic mice demonstrated baseline cardiac hypertrophy, dilation, interstitial fibrosis, apoptosis and progression towards heart failure in response to two surgery-induced …
Scalable Parallelization Of A Markov Coalescent Genealogy Sampler, Philip E. Davis
Scalable Parallelization Of A Markov Coalescent Genealogy Sampler, Philip E. Davis
Masters Theses
Coalescent genealogy samplers are effective tools for the study of population genetics. They are used to estimate the historical parameters of a population based upon the sampling of present-day genetic information. A popular approach employs Markov chain Monte Carlo (MCMC) methods. While effective, these methods are very computationally intensive, often taking weeks to run. Although attempts have been made to leverage parallelism in an effort to reduce runtimes, they have not resulted in scalable solutions. Due to the inherently sequential nature of MCMC methods, their performance has suffered diminishing returns when applied to large-scale computing clusters. In the interests of …
Genetic Structure Of Yellow Perch Populations In Coastal Areas Of Eastern Lake Michigan, Jessica N. Wesolek
Genetic Structure Of Yellow Perch Populations In Coastal Areas Of Eastern Lake Michigan, Jessica N. Wesolek
Masters Theses
Genetic population substructure is often overlooked because of discontinuities between management and actual population structure as in the case of yellow perch, an ecologically and economically important indigenous fish species in the Laurentian Great Lakes. A knowledge gaps pertaining to the natural history of yellow perch relates to the biological connectivity between nearshore Lake Michigan and drowned river mouth (DRM) lakes, where it remains unclear whether resident yellow perch from Lake Michigan use DRM lakes for spawning or whether DRM lakes contribute to nearshore yellow perch populations in Lake Michigan. I used DNA fingerprinting (genotyping) to explore biological connectivity between …
Microgeographic Population Genetic Structure Of Baylisascaris Procyonis (Nematoda: Ascaroidae) In Western Michigan Indicates The Grand River Is A Barrier To Gene Flow, Christina A. Sarkissian, Douglas H. Graham
Microgeographic Population Genetic Structure Of Baylisascaris Procyonis (Nematoda: Ascaroidae) In Western Michigan Indicates The Grand River Is A Barrier To Gene Flow, Christina A. Sarkissian, Douglas H. Graham
Student Summer Scholars Manuscripts
We developed eight polymorphic microsatellites from the parasitic nematode Baylisascaris procyonis. Amplification of these loci in a sample of 74 worms collected from 10 raccoons in Western Michigan revealed significant population structure. Bayesian clustering indicates two subpopulations, one on either side of the Grand River which bisects the region sampled. Estimates of FST, and results from AMOVA and isolation by distance, further corroborate a scenario whereby the river is acting as a barrier to gene flow, a rather unusual finding given the high vagility of raccoons and microgeographic scale of the analysis. We describe one possible mechanism …
Construction Of A Transgene To Analyze The Function Of The 3’Utr Of The Hdc Gene On Spatial Expression Of Histidine Decarboxylase In Drosophila Melanogaster, Embriette Hyde, Martin G. Burg
Construction Of A Transgene To Analyze The Function Of The 3’Utr Of The Hdc Gene On Spatial Expression Of Histidine Decarboxylase In Drosophila Melanogaster, Embriette Hyde, Martin G. Burg
Student Summer Scholars Manuscripts
Histamine has been shown to be an important neurotransmitter used in the nervous system of Drosophila melanogaster. Histidine decarboxylase (HDC) is the enzyme that catalyzes the synthesis of histamine. All genetic information necessary for Hdc gene expression has been shown to be present in a 9.4kb genomic DNA fragment. A previous study fused the 5'-UTR of Hdc to the gene encoding eGFP. Microscopic analysis of flies transformed with the pHdc-eGFP transgene showed a weak pattern of eGFP expression in the nervous system as compared to histamine localization, indicating that another genomic region may be necessary for robust Hdc expression. Studies …