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The Effects Of Selenium On Estrogen-Regulated Gene Expression In Lncap Prostate Cancer Cells, Tory L. Parker
The Effects Of Selenium On Estrogen-Regulated Gene Expression In Lncap Prostate Cancer Cells, Tory L. Parker
Theses and Dissertations
Prostate cancer is the most frequently diagnosed cancer in American men and the second leading cause of cancer deaths. Supplementation with Se has reduced the incidence of prostate cancer and Se status is inversely correlated with prostate cancer risk. One molecular mechanism by which high Se concentrations may affect cancer risk is by catalyzing disulfide bond formation or otherwise complexing with reactive sulfhydryl groups in cellular proteins. The estrogen receptor (ER) contains cysteines in zinc (Zn) fingers that are susceptible to oxidation and internal disulfide formation, which can prevent DNA binding. We examined ER binding to its DNA response element …