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Lung And Colon Cancer Chemoprevention By Polymethoxyflavones, Mingyue Song
Lung And Colon Cancer Chemoprevention By Polymethoxyflavones, Mingyue Song
Doctoral Dissertations
Cancer has been a leading cause of morbidity and mortality worldwide and characterized by the uncontrolled cell proliferation and an absence of cell death. Polymethoxyflavones (PMFs) is a unique class of flavonoids that almost exclusively found in the peel of citrus fruit. Studies have shown that PMFs exhibited numerous health promoting effects, including anti-carcinogenic and anti-inflammatory ones. Nobiletin (5,6,7,8,3’,4’-hexamethyoxflavone, NBT) is a major citrus flavonoid and has been the most studied PMFs for its potential health benefits. 5-Demethylnobiletin (5-hydroxy-6,7,8,3’,4’-pentamethoxyflavone, 5DN) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers. In this dissertation, we first …
Characterizing Colorectal Cancer Cells And Their Interactions With Polymethoxyflavones By Raman Microscopy, Hua Zhang
Doctoral Dissertations
Polymethoxyflavones (PMFs), especially Nobiletin (NBT) and 5-demethylnobiletin (5DN), have been widely studied and proved to have anti-cancer effects. However, their exact modes of action against cancer cells are not fully understood. Raman spectroscopy is a molecular vibrational spectroscopy can be used to measure overall biochemical function of single cells noninvasively and without adding any chemical labels. Herein, we characterized the cellular responses of human colorectal cancer HT29 and HCT116 cells, that grow on the gold coated slides, to the treatments of NBT and 5DN using Raman microscopy. Raman microscopic images obtained indicated the different modes of action of these two …