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Full-Text Articles in Life Sciences
Synergistic Actions Of Atorvastatin With Γ-Tocotrienol And Celecoxib Against Human Colon Cancer Ht29 And Hct116 Cells, Hang Xiao, Z. Yang, H. Jin, D. Tsang, P. Koo, C.S. Yang
Synergistic Actions Of Atorvastatin With Γ-Tocotrienol And Celecoxib Against Human Colon Cancer Ht29 And Hct116 Cells, Hang Xiao, Z. Yang, H. Jin, D. Tsang, P. Koo, C.S. Yang
Hang Xiao
The synergistic actions of atorvastatin (ATST) with gamma-tocotrienol (gamma-TT) and celecoxib (CXIB) were studied in human colon cancer cell lines HT29 and HCT116. The synergistic inhibition of cell growth by ATST and gamma-TT was demonstrated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and isobologram analysis. delta-TT exhibited a similar inhibitory action when combined with ATST. Mevalonate and geranylgeranyl pyrophosphate eliminated most of the growth inhibitory effect of ATST, but only marginally decreased that of gamma-TT; whereas farnesyl pyrophosphate and squalene exhibited little effect on the inhibitory action of ATST and gamma-TT, indicating protein geranylgeranylation, but not farnesylation are involved in the inhibition …
Cancer Prevention By Tea And Tea Polyphenols, Hang Xiao, C.S. Yang, J. Ju, G. Lu, X. Hao, S. Sang, J. Lambert
Cancer Prevention By Tea And Tea Polyphenols, Hang Xiao, C.S. Yang, J. Ju, G. Lu, X. Hao, S. Sang, J. Lambert
Hang Xiao
The inhibition of tumorigenesis by tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancer of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancrease, prostate, and mammary glands. Caffeine is also active in inhibition of tumorigenesis on the skin, lung, and perhaps other organs. In spite of many in vitro and in vivo studies, the molecular mechanisms for the cancer preventive actions of these compounds are not clearly known. The relationship between tea consumption and cancer risk has not been conclusively, and the relationship may become more clear if …