Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Anticancer Activity Of Branched-Chain Derivatives Of Oleic Acid, Oliver Daily, Xi Wang, Feng Chen, Guohui Huang
Anticancer Activity Of Branched-Chain Derivatives Of Oleic Acid, Oliver Daily, Xi Wang, Feng Chen, Guohui Huang
Feng Chen
Background: A number of unsaturated fatty acids and a few saturated branched-chain fatty acids have been reported to exhibit anticancer activity. Materials and Methods: In previously reported research, several novel branched-chain derivatives (methyl, n-butyl, phenyl) of methyl oleate were produced by bromination in the allylic position and subsequent treatment with organocuprate reagents. These compounds and their free acid counterparts were tested in vitro for their antiproliferative activities against two cancer cell lines: MCF-7 (human breast) and HT-29 (human colon). In addition, two sets of isomeric tertiary alcohols obtained as side-products in the synthesis of the branched-chain derivatives were evaluated. Testing …