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Full-Text Articles in Life Sciences
Insulin Resistance And T1d: The Effect Of Exercise On Skeletal Muscle Lipid Metabolism, Michelle Dotzert
Insulin Resistance And T1d: The Effect Of Exercise On Skeletal Muscle Lipid Metabolism, Michelle Dotzert
Electronic Thesis and Dissertation Repository
Insulin resistance is a characteristic of Type 2 Diabetes (T2D) and metabolic syndrome, and until recently has not been considered in the context of Type 1 Diabetes (T1D). A new classification, Double Diabetes, encompasses the presence of insulin resistance in T1D. Unfortunately, these individuals are at significantly higher risk of cardiovascular complications than those with T1D alone. In T2D, abnormal skeletal muscle lipid metabolism and the accumulation of insulin desensitizing lipid metabolites contribute the development of insulin resistance. There is some evidence to suggest this occurs in the context of T1D as well. Exercise training is an effective means to …
Effect Modification Of The Association Between Aerobic Physical Activity And Diabetes-Related Mortality By Race-Ethnicity: A Population-Based Prospective Study Using Nhanes Iii And 1999-2006 Nhanes, William Robert Boyer Ii
Effect Modification Of The Association Between Aerobic Physical Activity And Diabetes-Related Mortality By Race-Ethnicity: A Population-Based Prospective Study Using Nhanes Iii And 1999-2006 Nhanes, William Robert Boyer Ii
Doctoral Dissertations
Purpose: To examine potential effect modification by race-ethnicity of the relationship between physical activity (PA) and diabetes-related mortality risk using a sample of U.S. adults from the Third National Health and Nutrition Examination Survey (NHANES III). Methods: The sample (n=10,717) included adults (≥20 years) who attended the Mobile Examination Center (MEC). An age-standardized PA score (PAS) was calculated from the self-reported frequency and intensity of 12 leisure-time aerobic activities. The PA scores were then grouped into three categories: inactive (PAS = 0), insufficiently active (PAS >0 - Results: There was no interaction between PA and race-ethnicity (p=0.83). Compared to inactive …
Interfacing Continuous Measurement Of Glucose And Physical Activity To Predict Glycemic Control In Individuals With Type 2 Diabetes, Jennifer Blankenship
Interfacing Continuous Measurement Of Glucose And Physical Activity To Predict Glycemic Control In Individuals With Type 2 Diabetes, Jennifer Blankenship
Doctoral Dissertations
Physical activity is a cornerstone in the management of hyperglycemia and risk of cardiovascular disease in type 2 diabetes (T2D). However, the dose response relationship between physical activity and glucose regulation is not well defined. The overall goal of this dissertation was to assess the magnitude and timing of changes of daily glucose concentrations in response to continuous and intermittent light physical activity in T2D. Through utilizing continuous glucose monitors (CGM) and physical activity monitoring concurrently, we were able to assess the glycemic impact of physical activity and sedentary behavior in the free-living environment. Study 1 aimed to examine the …