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Full-Text Articles in Life Sciences
The Regulation Of Skeletal Muscle Fatigue During The Progression Of Cancer Cachexia, Brandon N. Vanderveen
The Regulation Of Skeletal Muscle Fatigue During The Progression Of Cancer Cachexia, Brandon N. Vanderveen
Theses and Dissertations
Cachexia is the unintentional loss of body weight secondary to chronic disease and is prevalent is roughly 50% of cancer patients. The loss of body weight and skeletal muscle mass is reduced functional capacity associated with reduced life quality. The etiology of cachexia is multimodal and complex; however, cachexia has been linked to several systemic (e.g. chronic inflammation, hypogonadism, anemia, insulin resistance) and behavioral (e.g. anorexia, inactivity) changes that can compound to accelerate muscle mass and body weight loss. While several inflammatory cytokines are associated with cachexia’s disease progression, our laboratory has established that Interleukin-6 (IL-6) is a key regulator …
Effect Of Trb3 On Skeletal Muscle Mass Regulation And Exercise-Induced Adaptation, Ran Hee Choi
Effect Of Trb3 On Skeletal Muscle Mass Regulation And Exercise-Induced Adaptation, Ran Hee Choi
Theses and Dissertations
Skeletal muscle, which composes over 40% of body mass, is responsible for daily locomotion and energy metabolism. It is a malleable tissue that can adapt its structure and function in response to internal and external environmental stimuli. Changing muscle mass and energy substrate utilization is a common skeletal muscle adaptation in response to various pathological conditions, including type 2 diabetes and obesity. Failure to maintain skeletal muscle mass and function has been correlated with increasing morbidity and mortality, as well as poor quality of life. Hence, maintenance of skeletal muscle integrity is a recommended strategy in achieving better quality of …
The Effects Of A Game Simulation On Muscle Activation And Knee Kinematics In Females, Geoffrey Collins
The Effects Of A Game Simulation On Muscle Activation And Knee Kinematics In Females, Geoffrey Collins
Theses and Dissertations
Intro: Female athletes experience non-contact ACL injuries at 5 times the rate of male athletes. These injuries occur more frequently at the end of halves and may be associated with exercise-induced fatigue causing knee instability. The purpose of this pilot study was to determine the effect of strenuous exercise on lateral knee movement during the landing phase of a jump. Methods: Ten subjects completed both the exercise and the control trial consisting of two 25-min game simulations on a treadmill or on a separate day the equivalent rest. Before, at half time, and immediately following the interventions subjects performed sets …
Muscle Inflammatory Signaling Regulates Eccentric Contraction-Induced Protein Synthesis During Cancer Cachexia, Justin Perry Hardee
Muscle Inflammatory Signaling Regulates Eccentric Contraction-Induced Protein Synthesis During Cancer Cachexia, Justin Perry Hardee
Theses and Dissertations
Cancer-related cachexia is a complex metabolic syndrome that involves the unintentional loss of skeletal muscle mass that cannot be reversed by standard nutritional intervention. Skeletal muscle mass depletion directly impacts patient survival and life quality, and therefore treatments that preserve muscle mass and function may have significant implications for cancer patient treatment and survival. Systemic and muscle inflammation has been implicated in the regulation of skeletal muscle homeostasis, and the cytokine interleukin-6 (IL-6) and muscle gp130 receptor signaling have established roles in cancer-induced muscle wasting. Resistance exercise is a nonpharmacological treatment that can improve physical function and metabolic health in …
Fiber Type-Specific Desmin Content In Human Single Muscle Fibers, Heidi Ghent
Fiber Type-Specific Desmin Content In Human Single Muscle Fibers, Heidi Ghent
Theses and Dissertations
Contractile and cytoskeletal protein concentrations have been shown to differ on the basis of fiber type in whole muscle homogenates. The purpose of this study was to compare the content of the intermediate filament protein, desmin, between type I and type IIa single muscle fibers from a mixed muscle in human subjects. Biopsies were taken from the vastus lateralis of six recreationally active males. Approximately 150 single muscle fibers were dissected from each sample and analyzed using SDS-PAGE to determine myosin heavy chain (MHC) composition. Following identification, muscle fibers were pooled into two groups (MHC I and MHC IIa). Desmin …