Life Sciences Commons^™

Early And Late Rapid Torque Characteristics And Select Physiological Correlates In Middle-Aged And Older Males, Alex A. Olmos, Matthew T. Stratton, Phuong L. Ha, Benjamin E. Dalton, Trisha Vandusseldorp, Gerald Mangine, Yuri Feito, Micah J. Poisal, Joshua A. Jones, Tyler M. Smith, Garrett Hester

Faculty and Research Publications

Purpose

The purpose of this study was to compare early and late rapid torque parameters of the plantar flexors (PFs) in middle-aged (MM) and older (OM) males, and determine the effect of normalization to peak torque (PT) and muscle cross-sectional area (CSA).

Methods

Twenty-nine healthy, MM (n = 14; 45 ± 2 yrs) and OM (n = 15; 65 ± 3 yrs) performed rapid, maximal isometric contractions of the PFs. PT, as well as rate of torque development and impulse during the early (0–50 ms; RTD_0-50, IMP_0-50) and late (100–200 ms; RTD_100-200, IMP_{100-200 …}

Autophagy And Aging: Maintaining The Proteome Through Exercise And Caloric Restriction, Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier, Trisha A. Vandusseldrop

Faculty and Research Publications

Accumulation of dysfunctional and damaged cellular proteins and organelles occursduring aging, resulting in a disruption of cellular homeostasis and progressive degen-eration and increases the risk of cell death. Moderating the accrual of these defunctcomponents is likely a key in the promotion of longevity. While exercise is knownto promote healthy aging and mitigate age‐related pathologies, the molecular under-pinnings of this phenomenon remain largely unclear. However, recent evidencessuggest that exercise modulates the proteome. Similarly, caloric restriction (CR), aknown promoter of lifespan, is understood to augment intracellular protein quality.Autophagy is an evolutionary conserved recycling pathway responsible for thedegradation, then turnover of cellular proteins …