Life Sciences Commons^™

Changes In Fitness-Fatness Index Following A Personalized, Community-Based Exercise Program In Physically Inactive Adults: A Randomised Controlled Trial, Abbey M. Jones, Lance C. Dalleck, Ryan M. Weatherwax, Joyce S. Ramos

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 1418-1429, 2022. Fitness-fatness index (FFI) is used to identify those at high risk of developing type 2 diabetes and cardiovascular events. It is measured as the ratio between an individual’s cardiorespiratory fitness (CRF) and waist-to-height ratio. Studies suggest that CRF and waist-to-height ratio are modifiable and can be improved by exercise. However, there is limited evidence surrounding a personalized approach to exercise prescription. This study investigated the impact of a 12-week personalized exercise program on FFI among sedentary individuals. It was hypothesized that the intervention would be effective in improving FFI in this cohort. …

Resistance Training As Therapeutic Management In Women With Pcos: What Is The Evidence?, Pamela J. Wright, Cynthia F. Corbett, Bernardine M. Pinto, Robin M. Dawson, Michael Wirth

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 840-854, 2021. Polycystic ovary syndrome (PCOS), the most common chronic endocrinopathy and the leading cause of infertility in women, has significant clinical consequences, including cardiovascular, endocrinological, oncological, and psychological co-morbidities. Endocrine Society Clinical Practice Guidelines on the Diagnosis and Treatment of PCOS recommend exercise and physical activity as first-line treatment to combat chronic disease risk. However, details about what type of exercise are not provided. Given the known beneficial effects of resistance training on the management of other chronic diseases, the purpose of this scoping review was to evaluate the scientific evidence about the …

Outdoor Time Is Not Associated With Metabolically Healthy Overweight And Obesity Phenotype In Canadian Children Aged 6-14 Years, Brittany Rioux, Neeru Gupta, Danielle Bouchard, James Dunbar, Martin Senechal

International Journal of Exercise Science

International Journal of Exercise Science 13(2): 383-394, 2020. A large proportion of children living with obesity have favorable cardiometabolic profiles despite their adiposity levels, who are referred to as metabolically healthy overweight or obese (MHO). However, the contribution of active outdoor time to the MHO phenotype is unknown. The purposeof this study was to investigate the association between outdoor time and moderate-to-vigorous physical activity (MVPA) with the MHO phenotype. A cross-sectional analysis of overweight/obese children aged 6-14 (n= 386) from the Canadian Health Measures Survey was performed. Outdoor time was self-reported using five questions in relation to …

Insulin Responsiveness In Metabolic Syndrome After Eight Weeks Of Cycle Training, Charles A. Stuart, Mark A. South, Michelle L. Lee, Melanie P. Mccurry, Mary E. A. Howell, Michael W. Ramsey, Michael H. Stone

Mark A. South

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome.

Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training.

Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not …

Cardiovascular Disease Risk Factors And Physical Fitness In Volunteer Firefighters, Zachary T. Martin, Rebecca A. Schlaff, Jade K. Hemenway, Jillian R. Coulter, Jeremy L. Knous, John E. Lowry, Joshua J. Ode

International Journal of Exercise Science

International Journal of Exercise Science 12(2): 764-776, 2019. Forty-seven percent of volunteer firefighter line of duty deaths are caused by cardiovascular events. Aggressive cardiovascular disease (CVD) risk factor reduction and improved physical fitness could reduce CVD mortality within this population. We assessed CVD risk factors and physical fitness in a large cohort of volunteer firefighters to help establish a health and fitness profile of this population, which may serve as evidence for the need to initiate programs aimed at reducing morbidity and mortality caused by CVD in the volunteer fire service. Seventy-four male volunteer firefighters were assessed for eight CVD …

Insulin Responsiveness In Metabolic Syndrome After Eight Weeks Of Cycle Training, Charles A. Stuart, Mark A. South, Michelle L. Lee, Melanie P. Mccurry, Mary E. A. Howell, Michael W. Ramsey, Michael H. Stone

Michael W. Ramsey

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome.

Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training.

Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not …

Exercise Training Prevents The Perivascular Adipose Tissue-Induced Aortic Dysfunction With Metabolic Syndrome, Evan Devallance, Kayla W. Branyan, Kent C. Lemaster, Ray Anderson, Kent L. Marshall, I. Mark Olfert, David M. Smith, Eric E. Kelly, Randy W. Bryner, Jefferson C. Frisbee, Paul D. Chantler

Faculty & Staff Scholarship

The aim of the study was to determine the effects of exercise training on improving the thoracic perivascularadipose tissue (tPVAT) phenotype (inflammation, oxidative stress, and proteasome function) in metabolic syn-drome and its subsequent actions on aortic function.Methods:Lean and obese (model of metabolic syndrome) Zucker rats (n=8/group) underwent 8-weeks ofcontrol conditions or treadmill exercise (70% of max speed, 1 h/day, 5 days/week). At the end of the inter-vention, the tPVAT was removed and conditioned media was made. The cleaned aorta was attached to a forcetransducer to assess endothelium-dependent and independent dilation in the presence or absence of tPVAT-conditioned media. tPVAT gene …

A Pre-Exercise Dose Of Melatonin Can Alter Substrate Use During Exercise, Cardyl P. Trionfante, Greggory R. Davis, Tyler M. Farney, Ryan W. Miskowiec, Arnold G. Nelson

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1029-1037, 2017. Notwithstanding the lack of exercise research, several reviews have championed the use of melatonin to combat metabolic syndrome. Therefore, this study compared substrate utilization during a 30-minute (min) graded exercise protocol following the ingestion of either 6 mg melatonin (M) or a placebo (P). Participants (12 women, 12 men) performed stages 1-5 of the Naughton graded exercise protocol (6 min per stage). The protocol was repeated 4 times (2x M, 2x P) at the same time of day with one week separating each session. Expired gases were monitored, VO₂ and respiratory …

Insulin Resistance And Muscle Insulin Receptor Substrate-1 Serine Hyperphosphorylation, Charles A. Stuart, Mary E. A. Howell, Brian M. Cartwright, Melanie P. Mccurry, Michelle L. Lee, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

Insulin resistance in metabolic syndrome subjects is profound in spite of muscle insulin receptor and insulin-responsive glucose transporter (GLUT4) expression being nearly normal. Insulin receptor tyrosine kinase phosphorylation of insulin receptor substrate-1 (IRS-1) at Tyr896 is a necessary step in insulin stimulation of translocation of GLUT4 to the cell surface. Serine phosphorylation of IRS-1 by some kinases diminishes insulin action in mice. We evaluated the phosphorylation status of muscle IRS-1 in 33 subjects with the metabolic syndrome and seventeen lean controls. Each underwent euglycemic insulin clamps and a thigh muscle biopsy before and after 8 weeks of either strength or …

Insulin Responsiveness In Metabolic Syndrome After Eight Weeks Of Cycle Training, Charles A. Stuart, Mark A. South, Michelle L. Lee, Melanie P. Mccurry, Mary E. A. Howell, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome.

Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training.

Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not …

Association Of Cardiovascular Fitness And Metabolic Syndrome In Male Police Officers, Matthew S. Schmidt, Steve Martin

International Journal of Exercise Science: Conference Proceedings

Metabolic syndrome has been shown in numerous studies to be related to a higher incidence of coronary artery disease (CAD). A study by Jurca and coworkers (Med. Sci. Sports Exerc 36(8):1301-1307, 2004) found a relationship between aerobic fitness and the prevalence of metabolic syndrome in a group of men enrolled in the Aerobics Center Longitudinal Study (ACLS). In addition, recent work in our lab (Int J Exerc Sci 2(1): S43, 2009) has supported these findings. However, research exploring this relationship is still lacking in male police officers. Previous research has suggested that the prevalence of CAD in police …

Association Of Cardiovascular Fitness And Syndrome X In Male Firefighters, Adam C. Sanchez, Steven E. Martin, Brad S. Lambert, Alex Carradine, John S. Green Facsm, Steve F. Crouse Facsm

International Journal of Exercise Science: Conference Proceedings

Metabolic syndrome has been shown in numerous studies to be related to a higher incidence of coronary artery disease. A study by Jurca and coworkers (Med. Sci. Sports Exerc 36(8):1301-1307, 2004) found a relationship between cardiovascular fitness and the prevalence of metabolic syndrome in a group of men enrolled in the Aerobics Center Longitudinal Study (ACLS). In addition, recent work in our lab (Int J Exerc Sci 2(1): S43, 2009) has supported these findings. However, research exploring this relationship is still lacking in male firefighters, whose leading cause of line-of-duty deaths is heart attacks. Purpose: To further …

Plasmatic E-Selectin Levels Were Decreased In Young Women With Metabolic Syndrome After Exercise Training, M Rosety-Rodriguez, I Rosety, G Fornieles-Gonzalez, J Meletis

International Journal of Exercise Science: Conference Proceedings

Cellular adhesion molecules (CAMs) such as E-selectin are involved in the rolling, adhesion and extravasation of monocytes into the atherosclerotic plaque. Fortunately regular exercise may improve pro-inflammatory status in individuals with metabolic syndrome. Accordingly, this study was designed to determine the influence of exercise on soluble plasmatic E-selectin levels in women with metabolic syndrome. Sixty adult women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-weeks aerobic training program, 3 days/week, consisting of warm up (10-min), …

Exercise Improves Endothelial Dysfunction In Young Women With Metabolic Syndrome, G Fornieles-Gonzalez, I Rosety, J Meletis, M A. Rosety

International Journal of Exercise Science: Conference Proceedings

Recent studies have reported that regular exercise reduces pro-inflammatory biomarkers in women with metabolic syndrome. However, to date little information is available on the influence of exercise on endothelial dysfunction, despite its important role during the development of atherosclerotic plaque. Accordingly, this study was designed to determine the influence of exercise on soluble vascular cell adhesion molecule (VCAM-1) in women with metabolic syndrome. Sixty adult women with metabolic syndrome according to the criteria reported by the National Cholesterol Education Program Adult Treatment Panel III volunteered for this study. Fourty-five were randomly included in experimental group to perform a 12-weeks aerobic …

Association Of Aerobic Fitness And Metabolic Syndrome In Male Firefighters, Christina Durcan, Jennifer M. Markos

International Journal of Exercise Science: Conference Proceedings

Association of Aerobic Fitness and Metabolic Syndrome in Male Firefighters. Durcan, C.M.*, S.E. Martin‡, B.S. Lambert†, N.P. Greene†, J.M. Markos†, A.F. Carbuhn†, J.S. Green‡, FACSM and S.F. Crouse‡, FACSM. Department of Health and Kinesiology, Texas A&M University, College Station, TX. Metabolic syndrome has been shown in numerous studies to be related to a higher incidence of coronary artery disease. A study by R. Jurca et.al., in Med. Sci. Sports Exerc 36(38), found a relationship between aerobic fitness and the prevalence of metabolic syndrome in a group of men enrolled in the Aerobics Center Longitudinal Study. Information on this relationship in …