Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Evolutionary Mechanisms For Host Resistance To Tumor Growth And Subsequent Cancer Cell Counter-Adaptations, Arig Ibrahim Hashim
Evolutionary Mechanisms For Host Resistance To Tumor Growth And Subsequent Cancer Cell Counter-Adaptations, Arig Ibrahim Hashim
USF Tampa Graduate Theses and Dissertations
Cancer is well-recognized as an evolutionary system, as first proposed by Cairns and Nowell more than 60 years ago. In an evolutionary context, cancers growing in vivo typically consist of heterogeneous subpopulations of cells that interact with each other and with host cells through selection forces operating at many temporal and spatial scales. Moreover, the tumor environment comprises more than just cancer cells; it includes a rich cancer stroma and cancer-driving molecules such as cytokines and metabolites. The tumor’s environment comprises intratumoral heterogeneity that often leads to therapy resistance attributed to the essential roles of many genetic and nongenetic mechanisms. …