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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Tracing Evolution Of Gene Transfer Agents Using Comparative Genomics, Roman Kogay
Tracing Evolution Of Gene Transfer Agents Using Comparative Genomics, Roman Kogay
Dartmouth College Ph.D Dissertations
The accumulating evidence suggest that viruses and their components can be domesticated by their hosts, equipping them with convenient molecular toolkits for various functions. One of such domesticated system is Gene Transfer Agents (GTAs) that are produced by some bacteria and archaea. GTAs morphologically resemble small phage-like particles and contain random fragments of their host genome. They are produced only by a small fraction of the microbial population and are released through a lysis of the host cell. Bioinformatic analyses suggest that GTAs are especially abundant in the taxonomic class of Alphaproteobacteria, where they are vertically inherited and evolve …
Causes And Consequences Of Lasr Mutant Selection In Pseudomonas Aeruginosa Populations, Dallas L. Mould
Causes And Consequences Of Lasr Mutant Selection In Pseudomonas Aeruginosa Populations, Dallas L. Mould
Dartmouth College Ph.D Dissertations
Change is the only constant in life, and these changes, though random in nature, can have consequences. Quorum sensing is heterogeneous in phenotype and prone to negative selection. In P. aeruginosa, the regulator LasR is frequently non-functional in phylogenetically diverse isolates. Through repeated experimental evolution and mathematical modeling, we show that differences in growth enable lasR mutant evolutionary success and this requires a system enabling metabolic choices, known as carbon catabolite repression (or catabolite repression). The differences in catabolite repression between wild type and lasR mutants enable altered metabolite preferences, and the resulting differences in metabolic states enable intraspecies …
Ecology And Evolution Of Social Information Use, Clare T. M. Doherty
Ecology And Evolution Of Social Information Use, Clare T. M. Doherty
Dartmouth College Ph.D Dissertations
Sociality is a strategy many animals employ to cope with their environments, enabling them to survive and reproduce more successfully than would otherwise be possible. When navigating their environments and making decisions, social individuals often use information provided by conspecifics (in the form of social cues and signals), thereby increasing the scope and reliability of the information they can gather. However, social information use may be influenced by many factors, including key differences in context across the physical and social environment. My thesis asks and answers a series of questions regarding the trade-offs in social information use across different contexts, …