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Introduction: Structural Properties For Determining Mechanisms Of Toxic Action, Steven P. Bradbury, Robert L. Lipnick

Steven P. Bradbury

The U.S. Environmental Protection Agency (EPA), under a variety of Federal legislation, is charged with the responsibility of assessing the hazards of chemicals to human health and the environment. In some cases EPA incorporates predictive techniques in its decisionmaking processes. In the context of some statutes, predictive toxicological methods can be cost-effective components in an overall approach for prioritizing chemicals for in-depth toxicological investigation. Predictive approaches are also used where empirical toxicological data are either unavailable or not required under a specific statute. For example, under Section 5 of the Toxic Substances Control Act (TSCA), EPA's Office of Toxic Substances …