Life Sciences Commons^™

Benzo(A)Pyrene Ingested From Composite Meals : Analysis And Method Development Related To Total Human Exposure, Che-Han Hsu

Theses

Polycyclic aromatic hydrocarbons including benzo[a]pyrene (BaP) have been known for many years to be environmental carcinogen. Moreover, B(a)P has often been used as an indi¬cator for the carcinogenic potency of environmental matter. One of its exposure pathways, ingestion, may possibly be more important than other routes, conventionally studied such as inhalation. The purposes of this thesis are 1) to analyze the B(a)P concentrations in weekly composite and some daily meals obtained in the Total Human Exposure to Environmental Substances (THEES) study, 2) to develop techniques which can measure the levels of B(a)P in foods accurately and effici¬ently, 3) to compare …

Study Of An Analytical Method For Benzo(A)Pyrene Metabolites In Human Urine, Zheng Ouyang

Theses

A method developed by Becher and Bjorseth for analysis of PAH metabolites in urine was employed to investigate human exposure to benzo(a)pyrene (BaP) - an ubiquitous environmental carcinogen. Preliminary results are presented showing the relationship between exposure to BaP and urinary elimination. Although the correlation between the two variables is not statistically significant, there appears to be a positive association with selected exposure varibles such as smoking. The identification of an association may establish urinary BaP as a marker of exposure.

However, detailed study of the analytical procedure indicated that recoveries with this method were as low as 3-8% for …