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Identification And Comparative Analysis Of Subolesin/Akirin Ortholog From Ornithodoros Turicata Ticks, Hameeda Sultana, Unnati Patel, Daniel E. Sonenshine, Girish Neelakanta
Identification And Comparative Analysis Of Subolesin/Akirin Ortholog From Ornithodoros Turicata Ticks, Hameeda Sultana, Unnati Patel, Daniel E. Sonenshine, Girish Neelakanta
Biological Sciences Faculty Publications
Background: Subolesin is an evolutionary conserved molecule in diverse arthropod species that play an important role in the regulation of genes involved in immune responses, blood digestion, reproduction and development. In this study, we have identified a subolesin ortholog from soft ticks Ornithodoros turicata, the vector of the relapsing fever spirochete in the United States.
Methods: Uninfected fed or unfed O. turicata ticks were used throughout this study. The subolesin mRNA was amplified by reverse transcription polymerase chain reaction (RT-PCR) and sequenced. Quantitative-real time PCR (QRT-PCR) was performed to evaluate subolesin mRNA levels at different O. turicata developmental stages …