Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Α-Glycerophosphate Cycle In Drosophila Melanogaster Iv. Metabolic, Ultrastructural, And Adaptive Consequences Of Αgpdh-1 "Null" Mutations, Stephen J. O'Brien, Yoshio Shimada
The Α-Glycerophosphate Cycle In Drosophila Melanogaster Iv. Metabolic, Ultrastructural, And Adaptive Consequences Of Αgpdh-1 "Null" Mutations, Stephen J. O'Brien, Yoshio Shimada
Biology Faculty Articles
"Null" mutations previously isolated at the αGpdh-1 locus of Drosophila melanogaster, because of disruption of the energy-producing α-glycerophosphate cycle, severely restrict the flight ability and relative viability of affected individuals. Two "null" alleles, αGpdh-1BO-1-4, and αGpdh-1BO-1-5, when made hemizygous with a deficiency of the αGpdh-1 locus,Df(2L)GdhA, were rendered homozygous by recombination with and selective elimination of the Df(2L)GdhA chromosome. After over 25 generations, a homozygous αGpdh-1BO-1-4stock regained the ability to fly despite the continued absence of …