Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Antibody (1)
- Antigenic determinants (1)
- Apoptosis (1)
- Auditory cortex (1)
- Bio-orthogonal chemistry (1)
-
- Cerebral cortex (1)
- Circular dichroism (1)
- Cognitive neuroscience (1)
- Colloids (1)
- Cortical electrophysiology (1)
- DNA hydrogel (1)
- Electrocorticography (1)
- Electroencephalography (1)
- Immunoglobulins (1)
- Intrabody (1)
- Long RNAs (1)
- Magnetic resonance microscopy (1)
- Monoclonal antibodies (1)
- Nanobody (1)
- Neuroscience (1)
- Nucleic acids (1)
- Oligonucleotide synthesis and purification (1)
- Oligonucleotides (1)
- Paramagnetic NMR (1)
- Patient monitoring (1)
- Proteins (1)
- Ribosome (1)
- Ribosomes (1)
- Ricin (1)
- Toxin (1)
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Legacy Theses & Dissertations (2009 - 2024)
Communication is a dynamic process through which we translate our inner thoughts in such a way that they can be shared with another person. This complex neurological phenomenon is a key predictor of our productivity and health. When our ability to communicate is compromised, our quality of life suffers. Although numerous methods to investigate the neuroscientific underpinnings of human language exist, our understanding of this process remains incomplete. Improving our understanding of where, when, and how auditory cortical activity occurs can enhance diagnostic techniques and improve treatment methods for neurological conditions that can impact auditory processing, such as epilepsy, or …
Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka
Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka
Legacy Theses & Dissertations (2009 - 2024)
Ricin is a highly lethal protein toxin derived from the seeds of the castor plant, Ricinus communis. It is a Type II ribosome inactivating protein (RIP), meaning it is a heterodimer with one subunit, ricin toxin B (RTB), that mediates cell surface attachment and intracellular trafficking and a second subunit, ricin toxin A (RTA), that irreversibly shuts down protein synthesis in the cytosol. During trafficking, RTA and RTB necessarily separate in the endoplasmic reticulum, wherein RTA unfolds and translocates into the cytosol where it refolds into an enzymatically active conformation. RTA is remarkably fast acting and efficient, with few molecules …
Development Of Chemical Methods For Oligonucleotide Purification, Paramagnetic Labeling And Synthesis Of Dna-Based Advanced Materials, Muhan He
Legacy Theses & Dissertations (2009 - 2024)
This thesis describes a chemical method for alternative oligonucleotide purification that is non-chromatographic and gel-free and allows to routinely synthesize and purify long functional RNA strands. The purification of long RNAs is based on the bio-orthogonal inverse electron demand Diels-Alder (IEDDA) chemistry between trans-cyclooctene (TCO) and tetrazine (Tz). Target oligonucleotide strands are selectively tagged with Tz and can be captured and purified from the failure sequences with immobilized TCO. RNA strands are synthesized on solid support through a photolabile linker to avoid the loss of Tz tag. Purity of the isolated oligonucleotides was evaluated using gel electrophoresis, HPLC and mass …