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Full-Text Articles in Life Sciences
Combined Effects Of Aerobic Exercise And 40-Hz Light Flicker Exposure On Early Cognitive Impairments In Alzheimer’S Disease Of 3×Tg Mice, Sang-Seo Park, Hye-Sang Park, Change-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim
Combined Effects Of Aerobic Exercise And 40-Hz Light Flicker Exposure On Early Cognitive Impairments In Alzheimer’S Disease Of 3×Tg Mice, Sang-Seo Park, Hye-Sang Park, Change-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim
Health and Kinesiology Faculty Publications
Alzheimer’s disease (AD) is a progressive degenerative brain disease and the primary cause of dementia. At an early stage, AD is generally characterized by short-term memory impairment, owing to dysfunctions of the cortex and hippocampus. We previously reported that a combination of exercise and 40-Hz light flickering can protect against AD-related neuroinflammation, gamma oscillations, reduction in Aβ, and cognitive decline. Therefore, we sought to extend our previous findings to the 5-mo-old 3×Tg-AD mouse model to examine whether the same favorable effects occur in earlier stages of cognitive dysfunction. We investigated the effects of 12 wk of exercise combined with 40-Hz …
Diabetes Mellitus Affects Working Memory, Dylone C. Braganza, Emmanuel Flores, Lauren A. Crew, Ryan A. Wirt, Andrew A. Ortiz, Adam M. Mcneela, Jefferson W. Kinney, James M. Hyman
Diabetes Mellitus Affects Working Memory, Dylone C. Braganza, Emmanuel Flores, Lauren A. Crew, Ryan A. Wirt, Andrew A. Ortiz, Adam M. Mcneela, Jefferson W. Kinney, James M. Hyman
Spectra Undergraduate Research Journal
Alzheimer’s disease (AD) degrades the brain’s ability to remember, think, and carry out tasks. The exact cause is not known, but several risk factors have been identified, including diabetes mellitus (DM). DM causes elevated blood sugar levels due to reduced insulin production in the pancreas. The linkage between elevated glucose levels and the behavioral impairments are not fully understood, which was the focus of this study. Rats were trained to alternate directions in a maze to receive a reward on consecutive trials. After training, five rats were injected with streptozotocin (STZ), which induces hyperglycemia by injuring pancreatic beta cells. Three …