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Drug Release And Its Relationship With Kinetic And Thermodynamic Parameters Of Drug Sorption Onto Polylactide, Starch Acetate, Wheat Gluten And Soy Protein Fibers, Weijie Xu
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto biodegradable and biocompatible fibers made of polylactic acid (PLA), starch acetate (SA), wheat gluten (WG) and soy protein (SP) have been studied using Diclofenac, 5 Fluorouracil (5-Fu) and Metformin as drug models. To understand drug release from these four fibers using sorption, kinetic and thermodynamic parameters, such as the diffusion coefficient, activation energy for diffusion, affinity, and sorption enthalpy and entropy, have been investigated. Quantitative relationship between drug release and drug loading concentration, affinity, and activation energy for diffusion was established to predict initial bursts and …