Life Sciences Commons^™

Constituent Partitioning Consensus Docking Models And Application In Drug Discovery, Rainer Metcalf

USF Tampa Graduate Theses and Dissertations

This work expounds on some of the current computational tools and programs available and the best practices associated with their use. A high-level introduction, intended for both novices and the semi-experienced, focusing on the more common programs used in scientific literature is the scope of this topic. Both classical and quantum techniques are described. Classical methodologies include Molecular Dynamics, Monte Carlo, energy minimization methods, molecular docking, low-mode, and homology modeling. Quantum chemistry techniques are also discussed encompassing Hartree-Fock, Post-Hartree-Fock theories, and Density Functional Theory along with associated basis sets.

Along with established methodologies, novel theoretical methods are introduced for furthering …

Amyloid Protein Aggregation And Associated Toxicity, Chamani A. Niyangoda

USF Tampa Graduate Theses and Dissertations

Amyloidosis is a group of diseases in which amyloid fibrils accumulate and deposit into plaques and intracellular inclusions which lead to disruption of the tissue architecture and function. Most of the amyloid diseases are incurable due to a lack of understanding of the amyloid formation, as well as associated toxicity. My research work is focused on three different aspects of amyloid aggregation.

The aim of the first project is to investigate the potential use of deep-blue autofluorescence (dbAF) as an intrinsic optical probe to study amyloid self-assembly. This novel fluorescence signal is excited at the long wavelength edge of the …

Paired Measures Of Competence And Confidence Illuminate Impacts Of Privilege On College Students, Rachel M. Watson, Edward Nuhfer, Kali Nicholas Moon, Steven Fleisher, Paul Walter, Karl Wirth, Christopher Cogan, Ami Wangeline, Eric Gaze

Numeracy

We seek to understand how the experiences of groups that differ in gender, ethnicity, and sexual orientation produce college-level educational performances that differ from the experiences of the dominant majority group. We employ two datasets: a National Database of 24,701 participants and a Paired-Measures Database with 3,323 participants. Both datasets provide demographic information, socioeconomic conditions of status as first-generation student, English as a first language, and interest in majoring in science, and competency scores on understanding science as a way of knowing obtained from the Science Literacy Concept Inventory. The Paired-Measures Database includes additional self-assessed competence ratings that enabled quantifying …

An Investigation Of The Effects Of The Parasitic Nematode Aplectana Hamatospicula On The Performance And Behavior Of Cuban Treefrogs (Osteopilus Septentrionalis), Kerri Surbaugh

USF Tampa Graduate Theses and Dissertations

Parasitic infections are ubiquitous in nature, and host-parasite dynamics can have powerful effects on wildlife populations. Many species have evolved behavioral responses to infection that can help mitigate damage from parasites. Anorexia is a common response to infection observed throughout the animal kingdom. Reducing nutrient intake can help shift host resources from digestion to immunity, as well as limit resources available to parasites. Reduced feeding can weaken the host, but in some host-parasite interactions, this cost is less than that of maintaining an infection. Here, I describe an experiment aimed to explore the effects of the parasitic nematode Aplectana hamatospicula …

La Ciencia Recreativa, "Historia De Un Pan De Azúcar" (1871), De José Joaquín Arriaga, Miguel A. Fernández Delgado Mafd

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

La "Historia de un pan de azúcar" (1871) es un capítulo de La Ciencia Recreativa, obra de divulgación para el público general creada por el mexicano José Joaquín Arriaga. Por medio de la fábula de los productos de una tienda que cobran vida, el autor describe la industria del azúcar y sus derivados en México.

The Modified Synchronization Modulation Technique Revealed Mechanisms Of Na,K-Atpase, Pengfei Liang

USF Tampa Graduate Theses and Dissertations

The Na/K pumps are essential for living system and widely expressed in all eukaryotic cell membranes. By actively transporting sodium ions out of and potassium ions into the plasma membrane, Na/K pumps creates both an electrical and a chemical gradient across the plasma membrane, which are crucial for maintaining membrane potential, cell volume, and secondary active transporting of other solutes, etc.

Previously, oscillating electric field with a frequency close to the mean physiological turnover rate was used to synchronize and modulate the Na/K pump molecules. Results showed that the turnover rate of Na/K pumps can be accelerated by folds. However, …

Investigating Student Conceptual Understanding Of Structure And Function By Using Formative Assessment And Automated Scoring Models, Kelli Patrice Carter

USF Tampa Graduate Theses and Dissertations

There has been a call from the national community of biologists and biology educators to increase biological literacy of undergraduate students, including understanding and application of core concepts. The structure and function relationship is a core concept identified by the wider biology community and by physiology faculty. Understanding of the core concept structure and function across multiple levels of organization may promote biological literacy. My research focused on the development of formative written assessment tools to provide insight into student understanding of structure and function in anatomy and physiology.

In chapter two I developed automated scoring tools to facilitate the …

Brave Spaces: Augmenting Interdisciplinary Stem Education By Using Quantitative Data Explorations To Engage Conversations On Equity And Social Justice, John R. Jungck, Jon Manon

Numeracy

In workshops and courses involving in-service teachers, participating teachers can engage in problem posing and exploration of difficult issues when they are asked to quantitatively model alternative scenarios, statistically analyze complex data, and visualize these data in multiple formats. Subsequent to these activities, discussions of sensitive issues, some even considered taboo in classrooms, can open up “brave spaces” in these teachers’ classrooms. Without coaching through elaborate facilitation strategies, the in-service teachers grappled openly with the nuances of such difficult issues and raised many alternatives involving quantitative reasoning as well as considering biological, cultural, economic, social, and political factors influencing social …