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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King
Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King
Arts & Sciences Electronic Theses and Dissertations
Understanding how genotype leads to phenotype is key to understand both the development and dysfunction of complex organisms. In the context of regulating the gene expression patterns that contribute to cell identity and function, the goal of my thesis research is to how changes in genome sequence may impact impact gene expression by determining how sequence features contribute to regulatory potential. To accomplish this goal, I first leveraged the key regulatory role of pluripotency transcription factors (TFs) in mouse embryonic stem cells (mESCs) and tested synthetically generated and genomic identified combinations of binding site for four TFs, OCT4, SOX2, KLF4, …
Genetic Basis Of Thermal Divergence In Saccharomyces Species, Xueying C. Li
Genetic Basis Of Thermal Divergence In Saccharomyces Species, Xueying C. Li
Arts & Sciences Electronic Theses and Dissertations
The genetic architecture of phenotypic divergence is a central question in evolutionary biology. Genetic architecture is impacted by whether evolution occurs through accumulation of many small-effect or a few large-effect changes, the relative contribution of coding and cis-regulatory changes, and the prevalence of epistatic effects. Our empirical understanding of the genetic basis of evolutionary change remains incomplete, largely because reproductive barriers limit genetic analysis to those phenotypes that distinguish closely related species. In this dissertation, I use hybrid genetic analysis to examine the basis of thermal divergence between two post-zygotically isolated species, Saccharomyces cerevisiae and S. uvarum. S. cerevisiae is …
Preventing Extinction Of At-Risk Plant Species In A Complex World, Holly Lee Bernardo
Preventing Extinction Of At-Risk Plant Species In A Complex World, Holly Lee Bernardo
Arts & Sciences Electronic Theses and Dissertations
Earthճ current biodiversity crisis is now considered a true mass extinction event, with species level extinction rates well above background rates and population level extinction rates orders of magnitude more common that species extinctions. There are many threats driving this loss of biodiversity. How each threat impacts the viability of a species is highly context dependent, but all are anthropogenic in origin and so as the human population continues to increase, so too will the pressure of these threats on our natural systems. Ultimately, how much a threat decreases the viability of a species depends on how that threat influences …
The Costs Of A Big Brain: How Region Scaling And Energetic Costs Influence Brain Size Evolution In Weakly Electric African Fishes (Mormyridae), Kimberley Varunee Sukhum
The Costs Of A Big Brain: How Region Scaling And Energetic Costs Influence Brain Size Evolution In Weakly Electric African Fishes (Mormyridae), Kimberley Varunee Sukhum
Arts & Sciences Electronic Theses and Dissertations
Brains control an organismճ ability to sense, remember, and respond to the frequently changing world. Brains are composed of multiple regions and systems, which are associated with different processes. These regions are homologous across all vertebrates yet vary greatly in size and shape across clades. While regions can function independently, they also interact extensively. These characteristics make it difficult to predict whether regions can change in size independently from other regions in response to selection (mosaic evolution hypothesis), or whether the brain evolves as a single concerted organ (concerted evolution hypothesis). Further, many traits such as cognition, behavioral flexibility, and …