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Ecology and Evolutionary Biology

Wayne State University

Wayne State University Dissertations

2020

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Full-Text Articles in Life Sciences

Evolutionary Ecology Of The Native Johnny Darter (Etheostoma Nigrum) And The Invasive Round Goby (Neogobius Melanostomus): A Genomic Perspective, Abby Joyce Wicks Jan 2020

Evolutionary Ecology Of The Native Johnny Darter (Etheostoma Nigrum) And The Invasive Round Goby (Neogobius Melanostomus): A Genomic Perspective, Abby Joyce Wicks

Wayne State University Dissertations

Round goby (Neogobius melanostomus) is an invasive fish present in all five Great Lakes and is becoming increasingly common in their tributaries. Johnny darter (Etheostoma nigrum) is a native species that often coexists with round goby. Here, I use traditional population genetic methods and genomic tools to explore the evolutionary ecology of these species. First, historic factors are addressed as a source of variation in study populations by characterizing patterns of mitochondrial DNA variation throughout Lower Michigan. Round goby populations were largely homogenous and exhibited no evidence of overarching historical genetic structure, consistent with the recent invasion and rapid expansion …


Development Of A Novel Cardiac Ischemia-Reperfusion Model In The Axolotl, Jeremy Tolentino Llaniguez Jan 2020

Development Of A Novel Cardiac Ischemia-Reperfusion Model In The Axolotl, Jeremy Tolentino Llaniguez

Wayne State University Dissertations

The Center for Disease Control’s National Center for Health Statistics data for mortality from diseases of the heart show the age-adjusted death rate has fallen from almost 600 deaths in the 1950s to just over 190 deaths per 100,000 U.S. residents today. With the recognized limitations of pharmacotherapy of myocardial infarction (MI), cell-based therapies have been undergoing rapid development and clinical testing. However, there is still no consensus about cell types, delivery routes, dosing and treatment schedules and pretreatment conditioning of cells prior to administration. Furthermore, a fundamental question remains unanswered about the reasons for the poor capacity for myocardial …