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Skeletal Advance And Arrest In Giant Non-Metamorphosing African Clawed Frog Tadpoles (Xenopus Laevis: Daudin), Ryan Kerney, Richard Wassersug, Brian Hall

Ryan Kerney

This study examines the skeletons of giant non-metamorphosing (GNM) Xenopus laevis tadpoles, which arrest their development indefinitely before metamorphosis, and grow to excessively large sizes in the absence of detectable thyroid glands. Cartilage growth is isometric; however, chondrocyte size is smaller in GNM tadpoles than in controls. Most cartilages stain weakly with alcian blue, and several cartilages are calcified (unlike con- trols). However, cartilages subjacent to periosteum-derived bone retain strong affinities for alcian blue, indicat- ing a role for periosteum-derived bone in the retention of glycosaminoglycans during protracted larval growth. Bone formation in the head, limb, and axial skeletons is …