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Synthesis And Study Of Anticancer And Antioxidant Activities Of 2-Oxoquinoline Hydrazide Derivatives, Marwa Khalil Mohamed, Ezzeldin Mohamed S. Salem, Ibrahim Ahmed I. Ali

Makara Journal of Science

In this work, hydrazone, thiosemicarbazide, diamide, and dipeptide derivatives were prepared from the glycine and β-alanine hydrazide of 4-hydroxy-2-oxoquinoline. The desired derivative resulted from substitution, hydrazinolysis, condensation, and azide coupling reactions. The fabricated derivatives were screened for anticancer characteristics toward human’s colon carcinoma (HCT-116) cell line using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide viability assay, while antioxidant property was examined using an in vitro H₂O₂ scavenging method. The β-alanine hydrazide derivative 3a showed a remarkable IC₅₀ value of 18.8 μg/mL, whereas its corresponding thiosemicarbazide 5b exhibited moderate activeness with an IC₅₀ value of 26.89 μg/mL. Conversely, …