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Full-Text Articles in Life Sciences
Mitochondrial Distribution Of Glycine Receptors In Motor Neuron Cell Lines, Katsiaryna Milashevich
Mitochondrial Distribution Of Glycine Receptors In Motor Neuron Cell Lines, Katsiaryna Milashevich
Student Theses and Dissertations
Although non-essential, glycine plays an important role in major metabolic reactions and is most known for its anti-inflammatory effects. An accumulation of contemporary research has shown that glycine is able to stabilize membrane potential using glycine receptors at the cellular level and to protect mitochondrial function directly, whether it is from inflammation, heavy metal poisoning, or ischemia-induced neuroinflammation. In this research, the existence of a hypothetical mitochondrial glycine receptor is examined. Immunofluorescence imaging was used to examine the presence of the glycine receptor subunits alpha 1 and alpha 2 in both non- differentiated and differentiated neuroblastoma cell lines. The preliminary …
Review: The Bidirectional Relationship Between Mitochondrial Respiratory Chain Inhibition And Import Machinery Malfunction In Parkinson’S Disease, Grace Riggs, Deepa Dabir
Review: The Bidirectional Relationship Between Mitochondrial Respiratory Chain Inhibition And Import Machinery Malfunction In Parkinson’S Disease, Grace Riggs, Deepa Dabir
Honors Thesis
Parkinson’s Disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) portion of the ventral midbrain, the region of the brain largely responsible for motor control, executive cognitive function, and emotional limbic activity (Sonne 2020). SNpc dopaminergic neurons are more vulnerable than those in other regions due to their high energy demand arising from long, highly branched, unmyelinated axons (Pissadaki & Bolam 2013). They also have a higher basal rate of oxidative phosphorylation, which has been hypothesized to further increase vulnerability in cases of PD (Pacelli et al., 2015). One of the major …
Maternal Engineered Nanomaterial Inhalation Exposure: Cardiac Molecular Reprogramming In Progeny Through Epigenetic And Epitranscriptomic Mechanisms, Amina Kunovac
Graduate Theses, Dissertations, and Problem Reports
Introduction: Nano-titanium dioxide (TiO2), a prominently utilized engineered nanomaterial (ENM), is being employed for its physiochemical properties in several fields including the food industry, manufacturing, and biomedicine. As the prevalence of this ENM, and other particulate matter grows, so does the concern for antagonistic consequences on long-term heart function in vulnerable populations, which until now have not been investigated. Due to the reliance of the heart on the ATP generating capacity of mitochondria for contraction, understanding the role of mitochondrial bioenergetics and structure is pivotal in understanding the repercussions of particulate matter exposure during gestation. As the mass …