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Assessing Morphology Of Iprgcs After Traumatic Brain Injury, Brian Foresi, Matt Smith
Assessing Morphology Of Iprgcs After Traumatic Brain Injury, Brian Foresi, Matt Smith
Williams Honors College, Honors Research Projects
ipRGCs are retinal ganglion cells that project to visual processing centers of the brain for nonimage forming visual functions. The relation of ipRGCs to tramatic brain injury (TBI) is emerging as data has been published describing ipRGC functional changes in TBI affected military veterans. Major symptomologies of concussions, a mild form of TBI, also overlap with the function governed by sites in the brain with major ipRGC projection percentages. Assesing if a morphological change is occuring in the ipRGCs after a TBI could support the idea of a pathological mechanism of the injury. This study could also indicate further relevance …
Investigating The Morphology Of Iprgcs In Control Vs. Glaucomatous Retinas, Samantha Cook
Investigating The Morphology Of Iprgcs In Control Vs. Glaucomatous Retinas, Samantha Cook
Williams Honors College, Honors Research Projects
Glaucoma is a build-up of pressure in the eye that leads to the gradual loss of sight. The intention of this study was to investigate how glaucoma affects intrinsically photosensitive Retinal Ganglion Cells (ipRGCs). These cells contain melanopsin, a photopigment, that enables the cells to react to light. Four-month-old control and five-month-old glaucoma mice retinas were dissected, stained using primary and secondary antibodies, then traced using ImageJ’s Simple Neurite Tracer. There were no significant differences in soma size, total dendritic length, dendritic field size, and dendritic field diameter between control and glaucoma ipRGCs. However, further research is needed to provide …