Life Sciences Commons^™

Comparative Analytical Study Of Phytochemicals In Selected Antidiabetic Medicinal Plant Seeds In Sri Lanka, Gowri Rajkumar, Mihiri Rangika Jayasinghe, Vinotha Sanmugarajah

Pharmaceutical Sciences and Research

Medicinal plants are universally used in the management of various diseases in different medical practices. A varied diversity of compounds extracted from plants may show anticancer, antibacterial, and antidiabetic activities. Comparative laboratory studies and scientific approach of efficacy related to phytochemicals found in medicinal plants in Sri Lanka have not been reported yet. This study aims to evaluate the phytochemicals in selected four different plant seeds such as Syzygium cumini (L.) Skeels, Brassica alba (L.) Rabenh, Trigonella foenum-graecum L. and Nigella sativa L., which are used in the management of diabetes mellitus in Sri Lanka. The ethanol extracts of …

Student Pharmacists’ Emotional Responses And Coping During The Covid-19 Pandemic, Hannah E. Johnson, Deaundre Bumpass, Aric Schadler, Jeffrey Cain

Journal of Wellness

Introduction: Health professions students, including student pharmacists, have been impacted by the coronavirus disease 19 (COVID-19 pandemic) as schools have transitioned to remote learning and cancelled milestone events. During times of crises, media consumption and hobby participation also impact well-being. The adverse emotional responses and coping strategies of student pharmacists amidst the COVID-19 pandemic have not been evaluated, nor have factors that may contribute to emotional responses. The purpose of this study is to determine Doctor of Pharmacy students’ emotional responses and coping precipitated by the COVID-19 pandemic, and the influence of media use, working status, and participation in hobbies. …

The Association Of Rs187238, Rs19465518 And Rs1946519 Il-8 Polymorphisms With Acute Kidney Injury In Preterm Infants, Fiva Aprilia Kadi

BioMedicine

ABSTRACT

Background: Interleukin 18 (IL-18) promoter polymorphisms (-656G>T, -607C>A, and -137G>C) affect serum IL-18 (sIL-18) levels and are associated with renal injury.

Purpose: This study aimed to determine the diagnostic utility of sIL-18 and urine IL-18 (uIL-18) as biomarkers for acute kidney injury (AKI) and analyse the association of IL-18 polymorphisms to AKI in preterm infants.

Methods: Blood and urine samples were collected from 56 preterm infants with AKI and 56 without AKI to measure serum creatinine (SCr), sIL-18, and uIL-18. Genotyping of polymorphisms was performed and analysed, with AUC-ROCs analysis used to evaluate …

The Effect Of The Provision Of Bagea Enriched With Sea Urchin Gonads On Weight Gain In Toddlers Of The Bajo Ethnic, La Banudi, Suriana Koro, M. Anas Anasiru, Nurmiaty Nurmiaty

Indonesian Journal of Public Health Nutrition (IJPHN)

Cassava starch extract and sea urchin gonads can be used as ingredients for making various kinds of food formulas. This study aimed to develop cassava starch extract as a formula for making bagea added with sea urchin gonads which are rich in nutrients to make it good for child. This study was aimed at analyzing the effect of the provision of bagea enriched by sea urchin gonads on weight gain in toddlers of the Bajo community. In making the formula of bagea, the researchers used a quasi-experimental design. After the data were collected, they were then checked for feasibility, coded, …

Factors Determining Successful Exclusive Breastfeeding Among Working Mothers In Indonesia: An Exploration By Using Positive Deviance Concept: Analysis Of Secondary Data Of Demographic Health Survey Indonesia 2017, Melinda Mastan, Endang Laksminingsih Achadi

Indonesian Journal of Public Health Nutrition (IJPHN)

Despite the fact that exclusive breastfeeding brings a lot of benefits for infants and mothers, breastfeeding rates in Indonesia remain low, at 42% of all infants aged 0-5 months in 2012. This study aims to apply the positive deviance concept to explore the factors determining the success of exclusive breastfeeding among mothers in a high-risk group in Indonesia. The study used the cross-sectional, DHS 2017 data of 1.178 mothers with 0-5 months old infants in Indonesia. Chi-square and multiple logistic regression tests with 95% confidence intervals are used in identifying the factors associated with exclusive breastfeeding. Maternal working status is …

Faktor-Faktor Yang Berhubungan Dengan Kejadian Diare Pada Siswa Sekolah Dasar Di Kabupaten Lebak, Provinsi Banten, Indonesia, Ilham Ibrahim, Ratu Ayu Dewi Sartika, Triyanti Triyanti, Tria Astika Endah Permatasari

Indonesian Journal of Public Health Nutrition (IJPHN)

Diarrhea is an endemic disease that has the potential to create extraordinary events in a country, including Indonesia. The highest diarrhea case was found in Banten Province, namely in Lebak Regency, the highest number was in the school-age group. This study aims to determine the relationship between the incidence of diarrhea on children's characteristics, children's behavior characteristics, mother/family characteristics, and environmental characteristics. This study uses secondary data with a cross-sectional design with a total sample of 151 elementary school children. The research was conducted in Cidahu Village RT/RW 02/01 Karangkamulyan Village, Lebak Regency, Banten Province. The dependent variable is the …

An Effective Method To Predict Low Birth Weight In Indonesia Rural Area, Asyifa Robiatul Adawiyah, Kusharisupeni Djokosujono, Nur Alam, Novita Arie Setiawati

Indonesian Journal of Public Health Nutrition (IJPHN)

Antenatal care (ANC) is a compulsory program in Indonesia with minimally 4 times visits, unfortunately, regular Antenatal care visit at Kanjillo health center, South Sulawesi, Indonesia is still low. Most of the Low Birth Weight (LBW) cases in Indonesia happened in a rural-areas, where most of the women conducted the first visit ANC on the third trimester. This study aimed to determine the cut-off point of mother’s last trimester pregnancy weight for predicting as well as preventing low birthweight outcomes in the community. The research design was cross-sectional with secondary data taken from the Kanjilo health center, with 150 pregnant …

Relationship Of Age, Gender, And History Of Comorbid Diseases In Tb Patients Toward Self-Stigma Tb In Surakarta, Ignes Widowati, Balgis Balgis, Sri Mulyani

Indonesian Journal of Public Health Nutrition (IJPHN)

Tuberculosis (TB) infection in Indonesia has not been completely eradicated. It is challenging for those who suffer from TB to be away from self-stigma. This study aimed to determine the relationship between age factors, gender, and a history of comorbid diseases related to self-stigma. This was a cross sectional study using a Tuberculosis Stigma Assessment questionnaire. Total 50 respondents were obtained by purposive sampling technique. Inclusion criteria are TB patients or former patients aged 18 years to the elderly, male and female, without or having a history of comorbidities (HIV & DM). Quantitative-qualitative analysis, univariate and bivariate tests using Pearson …

An Investigation Of The Knowledge And Perceptions Of Arthritis Amongst The Student Population In Ireland., Laura Dunleavy, Máire Mccallion

SURE Journal: Science Undergraduate Research Experience Journal

Background: Arthritis is a term used to categorise many diseases that primarily affect joints. It is a highly prevalent disease worldwide with approximately 915,000 individuals living with it in Ireland. Support is vital and it is important that individuals in college have a good understanding of disabilities. Previous studies found that there is a lack of knowledge and awareness about rheumatic diseases amongst the general public, however, no studies focused on the student population.

Aim: To investigate students’ knowledge and perception of arthritis and to determine whether education and more awareness about arthritis is needed amongst students.

Methods: This was …

The Onset Of Exercise-Associated Hyponatremia And Individual Differences In Inappropriate Arginine Vasopressin Excretion: A Review Of Proposed Mechanisms, Michelle Stehman, Stephen A. Maris

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 2: Issue 1, Article 10, 2021. Exercise-associated hyponatremia (EAH) has been reported to develop during endurance events such as triathlons and marathons. As these events become more popular, the incidence of developing EAH also increases. The development of EAH is commonly associated with the overconsumption of hypotonic fluids such as water and tends to be more prevalent in females. There is also evidence to suggest the inappropriate secretion of arginine vasopressin (AVP) leading to water retention may predispose an individual for developing EAH, especially when coupled with the overconsumption of fluids. Recent research …

A Comparison Of The Evolution, Structure, And Function Of Sars-Cov And Sars-Cov-2 Spike Proteins, Tai Michaels

The Yale Undergraduate Research Journal

As the COVID-19 pandemic has developed into the largest pandemic of the twenty-first century, it has become apparent that this disease, caused by the SARS-CoV-2 virus, is unlike anything the modern world has faced before. Not only has the disease infected more than 16 million people worldwide, but its rapid spread has drawn global attention to the gaps in our understanding of its pathogenesis and the development of vaccines and treatments. One of the most important topics of research in the disease is the viral spike (S) protein which facilitates binding and entering host cells and plays a key role …

Demographics, Activities, And Environmental Factors Impact Burnout In A National Survey Of Emergency Medicine Residents, Nicole Battaglioli, Tim P. Moran, Simiao Li-Sauerwine

Journal of Wellness

Introduction: Burnout in emergency medicine and in residency training has been well-described. The impact of demographic, individual, and programmatic factors on burnout have not previously been determined in a national survey of emergency medicine residents. This study aimed to identify personal and environmental factors impacting resident burnout in a national sample of emergency medicine residents.

Methods: A prospective Emergency Medicine Resident Wellness Survey was administered in 2017. We surveyed respondents on demographic, personal, and environmental factors; each respondent also completed the Maslach Burnout Inventory - Human Services Survey. Linear regressions were used to identify variables associated with the Maslach Burnout …

An Investigation On The Irish Population’S Attitudes And Knowledge Towards Genetic Screening For Cancer, Emer Mccarthy, Ada Fleming, Dawn Hannah Cronin

International Undergraduate Journal of Health Sciences

Genetic mutations are alterations in DNA that may result in the development of a disease later in life. A BRCA gene is a tumour suppressor gene that helps to prevent the development of some cancers, particularly breast cancer. If a mutation occurs, this gene no longer functions at preventing these cancers. Genetic screening is when a population is tested for a mutation in an attempt to identify a group of people that are positive for the mutation. This can help identify cancer in different populations as well as track their inheritance. This study was conducted online, questioning the Irish populations …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021

International Undergraduate Journal of Health Sciences

The full June 2021 issue (Volume 1, Issue 1) of the International Undergraduate Journal of Health Sciences

Prophylactic Phage Therapy In Infant Rabbits Model Of Cholera, Sadeq Ag Kaabi Asst Prof Dr

Karbala International Journal of Modern Science

A number of 8 phages lytic of V. cholerae O1- biotype-EI-Tor, serotype Inaba were selected for the formulation of a phage cocktail. A phage cocktail composed of 8 phages was prepared and showed 100% inhibition of V. cholerae isolates comparing with a percentage ranged from 0-75% for every single phage in growth inhibition assay. The potential activity of phage cocktail of prophylactic therapy for infant rabbits model of cholera was evaluated through phage retention time and length of phage prophylaxis studies. Results have been showed that phage cocktail was potent in the prevention of development of cholera in infant rabbits …

Laser-Assisted Tooth Extraction In Patients With Impaired Hemostasis, Elena Larionova Dr., Ekaterina Diachkova Dr., Elena Morozova Prof., Albert Davtyan Dr., Svetlana Tarasenko Prof.

BioMedicine

Introduction: The provision of efficient dental care to patients with hemostatic disorders is tied to difficulties and problems such as prolonged bleeding after or during surgical manipulation.

Aim: This study aims to increase the efficiency of oral surgery in patients with thrombocytopenia with the use of erbium laser on different stages of tooth extraction.

Methods: Patients (n = 96) were selected for tooth extraction on an outpatient basis: patients with confirmed thrombocytopenia (age 44 ± 15.4, 19–74) were included in the 1st group, and patients without impaired hemostasis (age 47.6 ± 15.3, 19¬81) were included in the …

Microrna-26a-5p As A Potential Predictive Factor For Determining The Effectiveness Of Trastuzumab Therapy In Her-2 Positive Breast Cancer Patients, Sadra Samavarchi Tehrani, Ehsan Zaboli, Farzin Sadeghi, Soraya Khafri, Ansar Karimian, Mahnoosh Rafie, Hadi Parsian

BioMedicine

Background: Breast cancer (BC) is known as the most prevalence type of cancer among women. Trastuzumab, as a cancer drug, has been used broadly in human epidermal growth factor receptor 2 (HER-2) positive BC patients. On the other hand, accumulating evidence has demonstrated that microRNAs involved in pathogenesis BC. Hence, we aimed to investigate the effect of trastuzumab on the expression levels of microRNA-26a in HER-2positiveBC patients.

Methods: This study was conducted on HER-2 positive BC patients and HER-2 Negative BC patients. Serum expression of microRNA-26a were detected by real-time PCR. Then, we assessed the correlation of microRNA-26a level with …

Predictors Of Mortality In Hospitalized Covid-19 Patients: A Mexican Population-Based Cohort Study., Fernando Mesta Dr., Ángel Mario Coll Dr., Miguel Ángel Ramírez M.Sc., Livan Delgado-Roche Dr.

BioMedicine

Objectives. COVID-19 outbreak brings a challenge to healthcare systems. The sex, age, and cardiometabolic comorbidities have been considered risk factors for disease severity. To evaluate the association between risk factors with death as well the risk of death in hospitalized COVID-19 patients.

Methods. The present cross-sectional cohort study, includes hospitalized SARS‑CoV‑2 confirmed cases. Data analysis was performed using the National COVID‑19 Cases Report Database. Pearson´s χ² test and odds ratios (95% CI) were calculated to determine the association between variables. Thereafter, risk of death was evaluated by Cox proportional hazards model.

Results. A total of 67 …

Do Bagasi Change The Exclusive Breastfeeding Knowledge And Attitudes?, Wido Gamani, Laras Sitoayu, Rachmanida Nuzrina, Lintang Purwara Dewanti, Anugrah Novianti

Indonesian Journal of Public Health Nutrition (IJPHN)

The achievement of exclusive breastfeeding (EBF) in the world and in Indonesia is still low. One of the obstacles to EBF is that the mother works. Cooler bag is a familiar media for working mothers to provide breast milk. This research uses modified cooler bags which contain information on how to provide EBF for working mothers, called bagASI. This study aims to determine the effect of bagASI on the EBF knowledge and attitudes of working pregnant women. The research method is Quasi Experimental with Pre Test - Post Test and the number of respondents is 34 working pregnant women. Respondents …

Food Insecurity Associated With Double-Burden Of Malnutrition Among Women In Reproductive Age In Ciampea Sub-District, Bogor, West Java, Seala Septiani, Ismi Irfiyanti, Tran Thi Hai, Luh Ade Wiradnyani, Aria Kekalih, Paulus Daniel Sahanggamu

Indonesian Journal of Public Health Nutrition (IJPHN)

Double burdens of malnutrition among women have occurred across most developing countries including Indonesia. This study compared the associated factors among overweight and underweight of women in reproductive age (WRA) in rural Ciampea Sub-district, Bogor, West Java. This cross-sectional study surveyed the nutritional status of 575 mothers (16-49 years old) who have under two-years-old children. Nutritional status was assessed by body-mass-index (BMI) and mid-upper arm circumference (MUAC), food security status by US-Food Security Survey Module (US-FSSM), dietary intake by a single 24-H dietary recall. The prevalence of underweight, overweight, and obese among this group were 10%, 15.8%, and 34.2%. Food …

Factors Associated With Underweight Among Two Years Old Children In Dki Jakarta Province (Indonesian Family Life Survey 2014), Nabilla Atelya, Ratu Ayu Dewi Sartika, Winda Mulianingsih

Indonesian Journal of Public Health Nutrition (IJPHN)

A good health status, cognitive development, and productivity cannot be achieved without good nutrition. Nutritional status and its fulfilment of two years old children will be shaping the health status in the next age period. Unfortunately, nutritional problems like underweight is still a significant health problem in Indonesia, especially Special Capital Region of Jakarta. This study used secondary data achieved from Indonesian Family Life Survey 5 data in 2014. This study used a cross-sectional study design with a total of 135 samples of two years old children using a total sampling. Accordingly, the chi square test was used to find …

Fulfilment Of Minimum Acceptable Diet As Dominant Factor In Wasting In Children Aged 6–23 Months In Central Jakarta, Indonesia, 2019, Ervida Andina, Madinar Madinar, Endang Laksminingsih Achadi

Indonesian Journal of Public Health Nutrition (IJPHN)

Wasting is a form of acute malnutrition characterized by significant and rapid weight loss resulting from inadequate food intake and infectious diseases. This study was to investigate the factors associated with wasting in children aged 6–23 months and the dominant factor among these. The study followed a cross-sectional study design. A total sample of 261 children was selected using multistage random sampling from 13 integrated healthcare centres in six administrative villages located in three sub-districts of Central Jakarta. Data was collected by measuring body weight and height and questionnaires completed through interviews carried out by trained data collectors. This study …

Underweight In Child Aged 24-59 Months In North Sumatra: The 2014 Indonesia Family Life Survey Data, Salsabila Kurnianingtyas, Ratu Ayu Dewi Sartika, Winda Mulia Ningsih

Indonesian Journal of Public Health Nutrition (IJPHN)

Underweight has the biggest risk against burden of disease. The aim of the study was to determine the factors related with underweight in child aged 24-59 months lived in North Sumatra based on three characteristics caused an underweight; there are child characteristics, maternal characteristics, and parenting characteristics. This study used cross-sectional design and using chi-square statistical analysis. The sample used in this study was 280 child aged 24-59 months living in North Sumatra province, Indonesia. The data was obtained from 2014 Indonesian Family Life Survey collected by RAND Corporation. Prevalence of underweight in child aged 24-59 months lived in North …

Physical Activity Behavior Comparisons Between Adults With And Without Type 1 Diabetes, Cassandra M. Beattie, Jesse A. Stein, Katie Heinrich

Health Behavior Research

Physical activity (PA) is a widely accepted strategy to manage chronic diseases like type 1 diabetes; however, unique PA barriers likely result in lower PA levels among person(s) with type 1 diabetes (PWT1D), compared to person(s) without type 1 diabetes (PWOT1D). The integrated theory of health behavior change (ITHBC) (i.e., knowledge/beliefs, self-regulation, and self-management) provides a helpful framework for understanding PA and other health behaviors. This research aimed to determine differences in PA between adult PWT1D and PWOT1D, and characterize their PA-related behaviors using the ITHBC. Participants (N = 90; 86.7% female, 90% white) were recruited via social media …

Challenges And Opportunities In Food Safety-A Review, Iram Asim, Humaira Yasmeen

Journal of Bioresource Management

Food-borne diseases are the group of disorders that are caused by consuming food having microbial existence in it. So safe food handling is to make sure the lessening of detrimental effects in growth to the packaging of food to minimize health issues on consumers which otherwise can lead to large scale disease outburst. This review concludes the findings of the studies on how food is being handled from farm to fork, how airlines are contributing towards the spreading of diseases, how any negligence in any one of the steps can cause havoc to mankind in the light of the recent …

Synthesis Of 1-(4-Ethoxy-3-Methoxybenzyl)-1,10-Phenanthrolin-1-Ium Bromide And Its Evaluation As Antiplasmodium Through Heme Polymerization Inhibitory Activity (Hpia) Assay, Dhina Fitriastuti, Viny Alfiyah, Mustofa Mustofa, Jumina Jumina, Muhammad Idham Darussalam Mardjan

Makara Journal of Science

This study describes the development of N-benzyl-1,10-phenantrolinium salt as an antiplasmodium agent. The salt, that is, 1-(4-ethoxy-3-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide, was prepared using vanillin as the starting material in four simple synthetic steps. First, the alkylation of vanillin using diethyl sulfate produced 4-ethoxy-3-methoxybenzaldehyde in 79% yield. Second, the reduction of the protected vanillin by NaBH₄ through the grinding method allowed us to obtain 4-ethoxy-3-methoxybenzyl alcohol in 96% yield. Next, the bromination of the benzyl alcohol under solvent-free condition led to the formation of the corresponding benzyl bromide, which in turn underwent bimolecular nucleophilic substitution with 1,10-phenanthroline to produce the desired …

H1n1 Influenza Virus (Swine Flu): A Comprehensive Insight Into Escalating Catch-22 Scenarios, Muhammad Shahzaib, Ehsan Ul Haq

The University of Louisville Journal of Respiratory Infections

Introduction: Viruses have always been a major cause of various disastrous pandemics in mankind’s history. H1N1 became a threat when its original strain was first discovered back in the swine flu pandemic of 2009. It became highly catastrophic on a large scale because none of the therapeutic interventions and methodologies that were already present at the time were effective against the virus.

Methods: A vast amount of literature and research is available regarding H1N1 influenza from different reputable sources online. The data were gathered with the contrasting and relative situations of 1918 and 2009 pandemics in mind. The overall extracted …

Wellness Review 2020, Part 2, Brian Ferguson, Martin Huecker

Journal of Wellness

Introduction: This article comprises Part 2 of the Journal of Wellness review of 2020 wellness literature (July – December). In this review, JWellness editors continue the goal of offering a cohesive summary of recent publications within the wellness domain. We summarize new science and resilience initiatives published outside of JWellness that seek understanding of either burnout and its prevention or thriving in the medical community.

Methods: From the interval of 01 July – 31 Dec 2020, PubMed was queried for empirical research studies, review articles, and editorials in accordance with the following algorithm: an article was required to …

Environmentally Marginalized Populations: The "Perfect Storm" For Infectious Disease Pandemics, Including Covid-19, Gabriella Y. Meltzer, Oyemwenosa Avenbuan, Christina Awada, Oluwakemi B. Oyetade, Tricia Blackman, Simona Kwon Drph, Mph, Esther Erdei Phd, Judith T. Zelikoff Phd

Journal of Health Disparities Research and Practice

COVID-19 has exacted a severe toll on the United States population’s physical and mental health and its effects have been felt most severely among people of color and low socioeconomic status. Using illustrative case studies, this commentary argues that in addition to COVID-19 health disparities created by psychosocial stressors such as the inability to socially distance and access quality healthcare, environmental justice communities have the additional burden of disproportionate exposure to toxic contaminants that contribute to their higher risk of COVID-19. Environmental contaminants including heavy metals and persistent organic pollutants found contaminating their nearby environments can alter the immune response, …

Long-Term Dynamics Of The Kidney Disease Epidemic Among Hiv-Infected Individuals, Heather Gudaz, Henry A. Ogu, Elissa J. Schwartz

Spora: A Journal of Biomathematics

One of many risks facing HIV+ individuals is the development of kidney dysfunction and end stage kidney disease (ESKD). A differential equation-based mathematical model was developed to assess the impact of antiretroviral therapy on the progression to kidney disease and on reducing mortality due to kidney failure. Analytical and numerical predictions of long-term HIV+ ESKD prevalence show that therapy can lead to either extremely low levels of disease prevalence or increased prevalence, depending on drug efficacy levels and mechanisms of action. Maintenance of HIV+ ESKD prevalence below one individual is possible with sufficient efficacy (e.g., 99%) against the progression from …