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Hlhs Is Caused By The Up Regulation Of Hif1Α Due To Hypoxia Caused By A Polymorphism In Enos, Tyler J. Bruinsma, Kevin T. Curwick, Leah Ellman, Jared M. Grootwassink, Thomas M. O'Toole
Hlhs Is Caused By The Up Regulation Of Hif1Α Due To Hypoxia Caused By A Polymorphism In Enos, Tyler J. Bruinsma, Kevin T. Curwick, Leah Ellman, Jared M. Grootwassink, Thomas M. O'Toole
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Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect occurring in fewer than 0.5% of live births in the United States (Fruitman, 2000). It is characterized by a critically underdeveloped left ventricle with accompanying imperfections including septal defects, under-sized aorta, and underdeveloped bicuspid and aortic semilunar valves (Mayo Clinic Staff, 2012; CDC, 2013). HLHS is detectable on ultrasound at the end of the first trimester of pregnancy allowing for early diagnosis and potential treatment in utero. While a protocol involving three surgeries exists to treat the condition, there is no cure for HLHS. Even with treatment, many …