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Full-Text Articles in Life Sciences
Defining The Molecular Networks Necessary For Thymus Fate And Organogenesis, Kaitlin A. Reeh
Defining The Molecular Networks Necessary For Thymus Fate And Organogenesis, Kaitlin A. Reeh
Dissertations & Theses (Open Access)
The thymus and parathyroid (PT) glands originate from endodermal progenitors in the bilateral third pharyngeal pouches (3rd pps). By E11.5 during mouse development, cells committed to the thymus lineage express Foxn1 whereas PT-fated cells express Gcm2. While these transcription factors are required for organ-specific differentiation, the exact molecular mechanisms that specify endodermal progenitors to either the thymus or parathyroid lineage are not well defined. Tbx1 is initially expressed throughout the 3rd pp endoderm, as it is required for segmentation of the pharyngeal apparatus, but is downregulated in the thymus-fated domain by E10.5. Despite the widely held notion …
Merlin Mediated Regulation Of Hair Follicle Morphogenesis, Megan K. Fentress
Merlin Mediated Regulation Of Hair Follicle Morphogenesis, Megan K. Fentress
Dissertations & Theses (Open Access)
Epidermal homeostasis is paramount for the ongoing function of the skin as the primary barrier between a mammalian organism and the external environment. Homeostasis is achieved through a complex and delicate balance of cell death, cell proliferation and cell differentiation. Critical for regeneration and maintenance of the skin are epidermal stem cells. Within the epidermis two distinct stem cell compartments exist, the bulge and interfollicular/basal stem cell niches, which play a central role in the regeneration of the epidermis through self-renewal and contribution to the differentiated cells of the epidermis. The bulge stem cell niche is established early in epidermal …
Impact Of Differentiation Status Of Kidney Progenitors In Wilms Tumor Development, Le Huang
Impact Of Differentiation Status Of Kidney Progenitors In Wilms Tumor Development, Le Huang
Dissertations & Theses (Open Access)
Wilms tumor is one of the most common solid tumors in children. It is an embryonic cancer of the kidney and is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression analysis of a large panel of Wilms tumor patients has identified different subsets of Wilms tumors that are distinct in their clinical outcomes and gene expression signatures. These subsets express specific genes that correspond to different stages of differentiation during renal development, suggesting that Wilms tumors may arise from transformed cells …
Elucidating The Role Of Rumi And O-Glucosylation In The Drosophila Eye, Amanda Haltom
Elucidating The Role Of Rumi And O-Glucosylation In The Drosophila Eye, Amanda Haltom
Dissertations & Theses (Open Access)
Rumi is a protein O-glucosyltransferase that adds the sugar O-glucose onto the serine in the target sequence C-S-X-S-(P/A)-C found within properly folded EGF repeats. It was first discovered to modify the Drosophila Notch extracellular domain and to be required for Notch signaling in a temperature dependent manner, but other targets of Rumi remained unknown. Several other proteins in the Drosophila proteome harbor multiple consensus sequence highly predictive of O-glucose, including the transmembrane protein Crumbs and the secreted protein Eyes shut (Eys). Both of these proteins are required for proper eye development and mutations in their human homologs …