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Full-Text Articles in Life Sciences
Antiviral Activities Andphosphorylation Of 5-Halo-2'-Deoxyuridines And N-Methanocarbathymidine In Cells Infectedwith Vaccinia Virus, Donald F. Smee, D. E. Humphreys, B. L. Hurst, Dale L. Barnard
Antiviral Activities Andphosphorylation Of 5-Halo-2'-Deoxyuridines And N-Methanocarbathymidine In Cells Infectedwith Vaccinia Virus, Donald F. Smee, D. E. Humphreys, B. L. Hurst, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
The Antipoxviral activities and phosphorylation of N-methanocarbathymidine ([N]-MCT) and four 5-halo-2'-deoxyuridines, namely 5-flouro- (FdU), 5-chloro- (CldU), 5-bromo- (BrdU), and 5-iodo- (IdU) derivatives were explored.
Interferon Alfacon 1 Inhibits Sars-Covinfection In Human Bronchial Epithelial Calu-3 Cells, Y. Kumaki, C. W. Day, M. K. Wandersee, B. P. Schow, J. S. Madsen, D. Grant, J. P. Roth, Donald F. Smee, L. M. Blatt, Dale L. Barnard
Interferon Alfacon 1 Inhibits Sars-Covinfection In Human Bronchial Epithelial Calu-3 Cells, Y. Kumaki, C. W. Day, M. K. Wandersee, B. P. Schow, J. S. Madsen, D. Grant, J. P. Roth, Donald F. Smee, L. M. Blatt, Dale L. Barnard
Animal, Dairy, and Veterinary Science Faculty Publications
The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In this report, interferon alfacon 1 was examined for inhibitory activities against SARS-CoV on human lung carcinoma epithelial Calu-3 cell line and the other three African green monkey kidney epithelial cell lines. Interferon alfacon 1 demonstrated significant antiviral activity in neutral red uptake assay and virus yield reduction assay. The data might provide an important …
Is The Anti-Psychotic, 10-(3-(Dimethylamino)Propyl)Phenothiazine (Promazine), A Dangerous Drug With Which To Treatsars Infections? Efficacy Of Promazine On Sars-Cov Replication In A Mouse Model, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, K. H. Jung, P. K. Chan, J. K. Li, R. W. Sidwell
Is The Anti-Psychotic, 10-(3-(Dimethylamino)Propyl)Phenothiazine (Promazine), A Dangerous Drug With Which To Treatsars Infections? Efficacy Of Promazine On Sars-Cov Replication In A Mouse Model, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, K. H. Jung, P. K. Chan, J. K. Li, R. W. Sidwell
Animal, Dairy, and Veterinary Science Faculty Publications
Phenothiazine and derivatives were tested for inhibition of SARS-CoV replication. Phenothiazine slightly inhibited SARS-CoV replication in a neutral red (NR) uptake assay. Adding a propylamino group to give promazine reduced virus yields (VYR assay) with an EC90 = 8.3 ± 2.8 μM, but without selectivity. Various substitutions in the basic phenothiazine structure did not promote efficacy. Phenazine ethosulfate was the most potent compound by VYR assay (EC90 = 6.1 ± 4.3 μM). All compounds were toxic (IC50 = 6.6–74.5 μM) except for phenoxathiin (IC50 = 858 ± 208 μM) and 10-(alpha-diethylamino-propionyl) phenothiazine·HCl (IC50 = 195 ± 71.2 μM). Consequently, none …
Youth Competitors Gain Benefits From Horse Show Judges' Training Program, Pat Evans, S. Mckendrick, J. Wesley, J. Smith
Youth Competitors Gain Benefits From Horse Show Judges' Training Program, Pat Evans, S. Mckendrick, J. Wesley, J. Smith
Animal, Dairy, and Veterinary Science Faculty Publications
This article details how youth benefit from a horse show judges’ training program. While judging is subjective, with training, judges can be more consistent in their placings, with the better horses and/or riders being placed at the top of the class. With qualified judges, youth can be more confident that they will be evaluated in a fair and consistent manner during each show all season long.