Life Sciences Commons^™

Spatial Semantics For Better Interoperability And Analysis: Challenges And Experiences In Building Semantically Rich Applications In Web 3.0, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Appearance Based Stage Recognition Of Drosophila Embryos, Gopi Chand Nutakki

Masters Theses & Specialist Projects

Stages in Drosophila development denote the time after fertilization at which certain specific events occur in the developmental cycle. Stage information of a host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene interaction. Manual labeling of stages is becoming a bottleneck under the circumstance of high throughput embryo images. Automatic recognition based on the appearances of embryos is becoming a more desirable scheme. This problem, however, is very challenging due to severe variations of illumination and gene expressions. In this research thesis, we propose an appearance …

Flexible Bootstrapping-Based Ontology Alignment, Prateek Jain, Pascal Hitzler, Amit P. Sheth

Kno.e.sis Publications

BLOOMS (Jain et al, ISWC2010) is an ontology alignment system which, in its core, utilizes the Wikipedia category hierarchy for establishing alignments. In this paper, we present a Plug-and-Play extension to BLOOMS, which allows to flexibly replace or complement the use of Wikipedia by other online or offline resources, including domain-specific ontologies or taxonomies. By making use of automated translation services and of Wikipedia in languages other than English, it makes it possible to apply BLOOMS to alignment tasks where the input ontologies are written in different languages.

The Mycobacterium Tuberculosis Drugome And Its Polypharmacological Implications, Sarah L. Kinnings, Li Xie, Kingston H. Fung, Richard M. Jackson, Lei Xie, Phillip E. Bourne

Publications and Research

We report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied to the genome of Mycobacterium tuberculosis (M.tb), the causative agent of one of today’s most widely spread infectious diseases. The resulting drug-target interaction network for all structurally characterized approved drugs bound to putative M.tb receptors, we refer to as the ‘TB-drugome’. The TB-drugome reveals that approximately one-third of the drugs examined have the potential to be repositioned to treat tuberculosis and that many currently unexploited M.tb receptors may be chemically druggable …

Ontology Alignment For Linked Open Data, Prateek Jain, Pascal Hitzler, Amit P. Sheth, Kunal Verma, Peter Z. Yeh

Kno.e.sis Publications

The Web of Data currently coming into existence through the Linked Open Data (LOD) effort is a major milestone in realizing the Semantic Web vision. However, the development of applications based on LOD faces difficulties due to the fact that the different LOD datasets are rather loosely connected pieces of information. In particular, links between LOD datasets are almost exclusively on the level of instances, and schema-level information is being ignored. In this paper, we therefore present a system for finding schema-level links between LOD datasets in the sense of ontology alignment. Our system, called BLOOMS, is based on the …

(1e,3e)-1,4-Bis(4-Methoxyphenyl)Buta1,3-Diene, Gopinathan Narayan, Nigam Rath, Suresh Das

Chemistry & Biochemistry Faculty Works

The title compound, C18H18O2, which exhibits blue emission in the solid state, is an inter­mediate in the preparation of liquid crystals and polymers. The mol­ecule is located on an inversion centre. In the crystal, mol­ecules are arranged in a herringbone motif.

Impact Of Interdisciplinary Undergraduate Research In Mathematics And Biology On The Development Of A New Course Integrating Five Stem Disciplines, Lester Caudill, April L. Hill, Kathy Hoke, Ovidiu Z. Lipan

Department of Math & Statistics Faculty Publications

Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was not only good science but also good science that motivated and informed course development. Here, we describe four recent undergraduate research projects involving students and faculty in biology, physics, mathematics, and computer science and how each contributed in significant ways to the conception and implementation of our new Integrated Quantitative Science course, a …

Impact Of Interdisciplinary Undergraduate Research In Mathematics And Biology On The Development Of A New Course Integrating Five Stem Disciplines, Lester Caudill, April L. Hill, Kathy Hoke, Ovidiu Z. Lipan

Biology Faculty Publications

Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was not only good science but also good science that motivated and informed course development. Here, we describe four recent undergraduate research projects involving students and faculty in biology, physics, mathematics, and computer science and how each contributed in significant ways to the conception and implementation of our new Integrated Quantitative Science course, a …

Drug Off-Target Effects Predicted Using Structural Analysis In The Context Of A Metabolic Network Model, Roger L. Chang, Lei Xie, Philip E. Bourne, Bernhard O. Palsson

Publications and Research

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of these two capabilities provides a framework for evaluating metabolic drug response phenotypes in silico. This combined approach was applied to investigate the hypertensive side effect of the cholesteryl ester transfer protein inhibitor torcetrapib in the context of human renal function. A metabolic kidney model was generated in which to simulate drug treatment. Causal drug off-targets were predicted that have previously been …

2,2′,5,5′-Tetra­Chloro­Benzidine, Onome Ugono, Marcel Douglas, Nigam Rath, Alicia Beatty

Chemistry & Biochemistry Faculty Works

In the crystal structure of the title compound, C12H8Cl4N2, mol­ecules lie on crystallographic twofold axes at the centre of the C-C bonds linking the benzene rings, such that the asymmetric unit consists of a half-mol­ecule. The individual mol­ecules participate in inter­molecular N-H...N, N-H...Cl, C-H...Cl and Cl...Cl [3.4503 (3) Å] inter­actions.

Bioinformatics Across The Sciences, Nigel Yarlett

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

A Taxonomy-Based Model For Expertise Extrapolation, Delroy H. Cameron, Boanerges Aleman-Meza, Ismailcem Budak Arpinar, Sheron L. Decker, Amit P. Sheth

Kno.e.sis Publications

While many ExpertFinder applications succeed in finding experts, their techniques are not always designed to capture the various levels at which expertise can be expressed. Indeed, expertise can be inferred from relationships between topics and subtopics in a taxonomy. The conventional wisdom is that expertise in subtopics is also indicative of expertise in higher level topics as well. The enrichment of Expertise Profiles for finding experts can therefore be facilitated by taking domain hierarchies into account. We present a novel semantics-based model for finding experts, expertise levels and collaboration levels in a peer review context, such as composing a Program …

Ranking Documents Semantically Using Ontological Relationships, Boanerges Aleman-Meza, I. Budak Arpinar, Mustafa V. Nural, Amit P. Sheth

Kno.e.sis Publications

Although arguable success of today’s keyword based search engines in certain information retrieval tasks, ranking search results in a meaningful way remains an open problem. In this work, the goal is to use of semantic relationships for ranking documents without relying on the existence of any specific structure in a document or links between documents. Instead, real-world entities are identified and the relevance of documents is determined using relationships that are known to exist between the entities in a populated ontology. We introduce a measure of relevance that is based on traversal and the semantics of relationships that link entities …

Cross-Market Model Adaptation With Pairwise Preference Data For Web Search Ranking, Jing Bai, Fernando Diaz, Yi Chang, Zhaohui Zheng, Keke Chen

Kno.e.sis Publications

Machine-learned ranking techniques automatically learn a complex document ranking function given training data. These techniques have demonstrated the effectiveness and flexibility required of a commercial web search. However, manually labeled training data (with multiple absolute grades) has become the bottleneck for training a quality ranking function, particularly for a new domain. In this paper, we explore the adaptation of machine-learned ranking models across a set of geographically diverse markets with the market-specific pairwise preference data, which can be easily obtained from clickthrough logs. We propose a novel adaptation algorithm, Pairwise-Trada, which is able to adapt ranking models that are trained …

Pattern Space Maintenance For Data Updates And Interactive Mining, Mengling Feng, Guozhu Dong, Jinyan Li, Yap-Peng Tan, Limsoon Wong

Kno.e.sis Publications

This article addresses the incremental and decremental maintenance of the frequent pattern space. We conduct an in-depth investigation on how the frequent pattern space evolves under both incremental and decremental updates. Based on the evolution analysis, a new data structure, Generator-Enumeration Tree (GE-tree), is developed to facilitate the maintenance of the frequent pattern space. With the concept of GE-tree, we propose two novel algorithms, Pattern Space Maintainer+ (PSM+) and Pattern Space Maintainer− (PSM−), for the incremental and decremental maintenance of frequent patterns. Experimental results demonstrate that the proposed algorithms, on average, outperform the representative state-of-the-art …

2,4,6-Triphenyl­Aniline, Onome Ugono, Stephanie Cowin, Alicia Beatty

Chemistry & Biochemistry Faculty Works

Individual mol­ecules of the title compound, C24H19N, do not participate in hydrogen-bonding inter­actions due to the steric bulk of the phenyl rings ortho to the amine. The dihedral angles between the central ring and the pendant rings are 68.26 (10), 55.28 (10) and 30.61 (11)°.

10302 Summary - Learning Paradigms In Dynamic Environments, Barbara Hammer, Pascal Hitzler

Computer Science and Engineering Faculty Publications

The seminar centered around problems which arise in the context of machine learning in dynamic environments. Particular emphasis was put on a couple of specific questions in this context: how to represent and abstract knowledge appropriately to shape the problem of learning in a partially unknown and complex environment and how to combine statistical inference and abstract symbolic representations; how to infer from few data and how to deal with non i.i.d. data, model revision and life-long learning; how to come up with efficient strategies to control realistic environments for which exploration is costly, the dimensionality is high and data …

Biomedical Ontologies For Parasite Research, Vinh Nguyen, Satya S. Sahoo, Priti Parikh, Todd Minning, Brent Weatherly, Flora Logan, Amit P. Sheth, Rick Tarleton

Kno.e.sis Publications

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease or American trypanosomiasis, which is the leading cause of death in Latin America. The primary objective of this study is to create an ontology-driven information infrastructure to support parasite researchers in identifying gene knockout, vaccination, or drug targets for T. cruzi. This involves querying across multiple datasets from diverse sources, such as proteome, pathway, internal lab data, etc. that are often represented in heterogeneous formats. To address this, a multi-ontology parasite knowledge repository (PKR) is being created with an intuitive graphical query interface called Cuebee. The PKR is underpinned by …

Cloud Based Scientific Workflow For Nmr Data Analysis, Ashwin Manjunatha, Paul E. Anderson, Satya S. Sahoo, Ajith Harshana Ranabahu, Michael L. Raymer, Amit P. Sheth

Kno.e.sis Publications

This work presents a service oriented scientific workflow approach to NMR-based metabolomics data analysis. We demonstrate the effectiveness of this approach by implementing several common spectral processing techniques in the cloud using a parallel map-reduce framework, Hadoop.

Trust Model For Semantic Sensor And Social Networks: A Preliminary Report, Pramod Anantharam, Cory Andrew Henson, Krishnaprasad Thirunarayan, Amit P. Sheth

Kno.e.sis Publications

Trust is an amorphous concept that is becoming Increasingly important in many domains, such as P2P networks, E-commerce, social networks, and sensor networks. While we all have an intuitive notion of trust, the literature is scattered with a wide assortment of differing definitions and descriptions; often these descriptions are highly dependent on a single domain or application of interest. In addition, they often discuss orthogonal aspects of trust while continuing to use the general term “trust”. In order to make sense of the situation, we have developed an ontology of trust that integrates and relates its various aspects into a …

Sit-To-Stand Detection Using Fuzzy Clustering Techniques, Tanvi Banerjee, James M. Keller, Marjorie Skubic, Carmen Abbott

Kno.e.sis Publications

The ability to rise from a chair is an important parameter to assess the balance deficits of a person. In particular, this can be an indication of risk for falling in elderly persons. Our goal is automated assessment of fall risk using video data. Towards this goal, we present a simple yet effective method of detecting transition, i.e. sit-to-stand and stand-to-sit, from image frames using fuzzy clustering methods on image moments. The technique described in this paper is shown to be robust even in the presence of noise and has been tested on several data sequences using different subjects yielding …

How To Make Linked Data More Than Data, Prateek Jain, Amit P. Sheth, Kunal Verma, Pascal Hitzler, Peter Z. Yeh

Kno.e.sis Publications

The LOD cloud has a potential for applicability in many AI-related tasks, such as open domain question answering, knowledge discovery, and the Semantic Web. An important prerequisite before the LOD cloud can enable these goals is allowing its users (and applications) to effectively pose queries to and retrieve answers from it. However, this prerequisite is still an open problem for the LOD cloud and has restricted it to 'merely more data.' To transform the LOD cloud from 'merely more data' to 'semantically linked data' there are plenty of open issues which should be addressed. We believe this transformation of the …

Semantically Annotated Restful Services For Large-Scale Metabolomics Data Analysis, Ashwin Manjunatha, Paul E. Anderson, Satya S. Sahoo, Ajith H. Ranabahu, Michael L. Raymer, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Janus: From Workflows To Semantic Provenance And Linked Open Data, Paolo Missier, Satya S. Sahoo, Jun Zhao, Carole Goble, Amit P. Sheth

Kno.e.sis Publications

Data provenance graphs are form of metadata that can be used to establish a variety of properties of data products that undergo sequences of transformations, typically specified as workflows. Their usefulness for answering user provenance queries is limited, however, unless the graphs are enhanced with domain-specific annotations. In this paper we propose a model and architecture for semantic, domain-aware provenance, and demonstrate its usefulness in answering typical user queries. Furthermore, we discuss the additional benefits and the technical implications of publishing provenance graphs as a form of Linked Data. A prototype implementation of the model is available for data produced …

Provenance Management In Parasite Research, Vinh Nguyen, Priti Parikh, Satya S. Sahoo, Amit P. Sheth

Kno.e.sis Publications

The objective of this research is to create a semantic problem solving environment (PSE) for human parasite Trypanosoma cruzi. As a part of the PSE, we are trying to manage provenance of the experiment data as it is generated. It requires to capture the provenance which is often collected through web forms used by biologists to input the information about experiments they conduct. We have created Parasite Experiment Ontology (PEO) that represents provenance information used in the project. We have modified the back end which processes the data gathered from biologists, generates RDF triples and serializes them into the triple …

Distance-Based Measures Of Inconsistency And Incoherency For Description Logics, Yue Ma, Pascal Hitzler

Computer Science and Engineering Faculty Publications

Inconsistency and incoherency are two sorts of erroneous information in a DL ontology which have been widely discussed in ontology-based applications. For example, they have been used to detect modeling errors during ontology construction. To provide more informative metrics which can tell the differences between inconsistent ontologies and between incoherent terminologies, there has been some work on measuring inconsistency of an ontology and on measuring incoherency of a terminology. However, most of them merely focus either on measuring inconsistency or on measuring incoherency and no clear ideas of how to extend them to allow for the other. In this paper, …

Some Trust Issues In Social Networks And Sensor Networks, Krishnaprasad Thirunarayan, Pramod Anantharam, Cory Andrew Henson, Amit P. Sheth

Kno.e.sis Publications

Trust and reputation are becoming increasingly important in diverse areas such as search, e-commerce, social media, semantic sensor networks, etc. We review past work and explore future research issues relevant to trust in social/sensor networks and interactions. We advocate a balanced, iterative approach to trust that marries both theory and practice. On the theoretical side, we investigate models of trust to analyze and specify the nature of trust and trust computation. On the practical side, we propose to uncover aspects that provide a basis for trust formation and techniques to extract trust information from concrete social/sensor networks and interactions. We …

Linked Sensor Data, Harshal Kamlesh Patni, Cory Andrew Henson, Amit P. Sheth

Kno.e.sis Publications

A number of government, corporate, and academic organizations are collecting enormous amounts of data provided by environmental sensors. However, this data is too often locked within organizations and underutilized by the greater community. In this paper, we present a framework to make this sensor data openly accessible by publishing it on the Linked Open Data (LOD) Cloud. This is accomplished by converting raw sensor observations to RDF and linking with other datasets on LOD. With such a framework, organizations can make large amounts of sensor data openly accessible, thus allowing greater opportunity for utilization and analysis.

Neuronbank: A Tool For Cataloging Neuronal Circuitry, Paul S. Katz, Robert Calin-Jageman, Akshaye Dhawan, Chad Frederick, Shuman Guo, Rasanjalee Dissanayaka, Naveen Hiremath, Wenjun Ma, Xiuyn Shen, Hsui C. Wang, Hong Yang, Sushil Prasad, Rajshekhar Sunderraman, Ying Zhu

Mathematics and Computer Science Faculty Publications

The basic unit of any nervous system is the neuron. Therefore, understanding the operation of nervous systems ultimately requires an inventory of their constituent neurons and synaptic connectivity, which form neural circuits. The presence of uniquely identifiable neurons or classes of neurons in many invertebrates has facilitated the construction of cellular-level connectivity diagrams that can be generalized across individuals within a species. Homologous neurons can also be recognized across species. Here we describe NeuronBank.org, a web-based tool that we are developing for cataloging, searching, and analyzing neuronal circuitry within and across species. Information from a single species is represented in …

Partitioning Of Minimotifs Based On Function With Improved Prediction Accuracy, Sanguthevar Rajasekaran, Tian Mi, Jerlin Camilus Merlin, Aaron Oommen, Patrick R. Gradie, Martin R. Schiller

Life Sciences Faculty Research

Background

Minimotifs are short contiguous peptide sequences in proteins that are known to have a function in at least one other protein. One of the principal limitations in minimotif prediction is that false positives limit the usefulness of this approach. As a step toward resolving this problem we have built, implemented, and tested a new data-driven algorithm that reduces false-positive predictions.

Methodology/Principal Findings

Certain domains and minimotifs are known to be strongly associated with a known cellular process or molecular function. Therefore, we hypothesized that by restricting minimotif predictions to those where the minimotif containing protein and target protein have …