Life Sciences Commons^™

Teloportwrapper: A New Tool For Understanding The Dynamic World Of Fungal Telomere Ends, Trey Stansfield

Mahurin Honors College Capstone Experience/Thesis Projects

Telomeres are repetitive DNA sequence motifs found at eukaryote chromosome ends. Telomeres help protect chromosome ends from DNA damage and promote chromosome stability. Chromosomes play important roles in aging, mutation, and cancer. Eukaryotic pathogens also use telomeres to mutate and manage virulence genes. In response to chromosome end breakage newly formed telomeres, called de novo telomeres, are formed to recreate the lost telomere and sub-telomeric regions.

Magnaporthe oryzae is a fungal pathogen which causes wheat blast, a deadly plant disease in wheat. Magnaporthe oryzae is also known for its highly variable sub-regions which show high amounts of induced variability due …

Inflammatory Bowel Disease Diagnosis Using Metagenomic Classification, Michael Riggle

Masters Theses & Specialist Projects

Inflammatory bowel disease (IBD) is a set of disorders that involve chronic inflammation of digestive tracts, e.g., Crohn's disease (CD) and ulcerative colitis (UC). Millions of people around the world have inflammatory bowel disease. However, it is still difficult to treat IBD due to its unknown cause. In fact, accurately diagnosing inflammatory bowel disease (IBD) can be very challenging too since some of IBD symptoms can mimic those of other conditions. In this work, we apply classification methods to help improve the success rate of diagnosis. We study four formulations of IBD classification: i) IBD and non-IBD (binary classification), ii) …

Development Of An Autonomous Aerial Toolset For Agricultural Applications, Terrance Life

Mahurin Honors College Capstone Experience/Thesis Projects

According to the United Nations, the world population is expected to grow from its current 7 billion to 9.7 billion by the year 2050. During this time, global food demand is also expected to increase by between 59% and 98% due to the population increase, accompanied by an increasing demand for protein due to a rising standard of living throughout developing countries. [1] Meeting this increase in required food production using present agricultural practices would necessitate a similar increase in farmland; a resource which does not exist in abundance. Therefore, in order to meet growing food demands, new methods will …

A Proposed Frequency-Based Feature Selection Method For Cancer Classification, Yi Pan

Masters Theses & Specialist Projects

Feature selection method is becoming an essential procedure in data preprocessing step. The feature selection problem can affect the efficiency and accuracy of classification models. Therefore, it also relates to whether a classification model can have a reliable performance. In this study, we compared an original feature selection method and a proposed frequency-based feature selection method with four classification models and three filter-based ranking techniques using a cancer dataset. The proposed method was implemented in WEKA which is an open source software. The performance is evaluated by two evaluation methods: Recall and Receiver Operating Characteristic (ROC). Finally, we found the …

An Apache Hadoop Framework For Large-Scale Peptide Identification, Harinivesh Donepudi

Masters Theses & Specialist Projects

Peptide identification is an essential step in protein identification, and Peptide Spectrum Match (PSM) data set is huge, which is a time consuming process to work on a single machine. In a typical run of the peptide identification method, PSMs are positioned by a cross correlation, a statistical score, or a likelihood that the match between the trial and hypothetical is correct and unique. This process takes a long time to execute, and there is a demand for an increase in performance to handle large peptide data sets. Development of distributed frameworks are needed to reduce the processing time, but …

An Automatic Framework For Embryonic Localization Using Edges In A Scale Space, Zachary Bessinger

Masters Theses & Specialist Projects

Localization of Drosophila embryos in images is a fundamental step in an automatic computational system for the exploration of gene-gene interaction on Drosophila. Contour extraction of embryonic images is challenging due to many variations in embryonic images. In the thesis work, we develop a localization framework based on the analysis of connected components of edge pixels in a scale space. We propose criteria to select optimal scales for embryonic localization. Furthermore, we propose a scale mapping strategy to compress the range of a scale space in order to improve the efficiency of the localization framework. The effectiveness of the proposed …

Contour Extraction Of Drosophila Embryos Using Active Contours In Scale Space, Soujanya Siddavaram Ananta

Masters Theses & Specialist Projects

Contour extraction of Drosophila embryos is an important step to build a computational system for pattern matching of embryonic images which aids in the discovery of genes. Automatic contour extraction of embryos is challenging due to several image variations such as size, shape, orientation and neigh- boring embryos such as touching and non-touching embryos. In this thesis, we introduce a framework for contour extraction based on the connected components in the gaussian scale space of an embryonic image. The active contour model is applied on the images to refine embryo contours. Data cleaning methods are applied to smooth the jaggy …

Appearance Based Stage Recognition Of Drosophila Embryos, Gopi Chand Nutakki

Masters Theses & Specialist Projects

Stages in Drosophila development denote the time after fertilization at which certain specific events occur in the developmental cycle. Stage information of a host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene interaction. Manual labeling of stages is becoming a bottleneck under the circumstance of high throughput embryo images. Automatic recognition based on the appearances of embryos is becoming a more desirable scheme. This problem, however, is very challenging due to severe variations of illumination and gene expressions. In this research thesis, we propose an appearance …

Ua66 2007 Student Awards Ceremony, Wku Ogden College Of Science & Engineering

WKU Archives Records

Program recognizing Ogden College students with brief list of activities for each student.

Ua35/11 Wku Student Honors Research Bulletin, Wku University Honors Program

WKU Archives Records

The Western Kentucky University Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers represent work done by students from throughout the university.

• Kesselring, Marcia. Attitudes Toward the Need for Computer Literacy
• Tuck, Janna & Karen Wiggins. Methylation and Confirmation of PGE
• Lewis, Gloria. John Donne's Attitude Toward Love
• Johnson, Linda. International Telecommunications Trade with Japan
• Sharpe, Greg. Precipitation Patterns in Bowling Green, Kentucky, 1980-1985
• Smith, Sandy. Religion and the Media: Alliance or War?
• Bell, Suzanne. Early Secret Involvement of the United States Military in Cambodia
• Scariot, Linda. Parental Divorce and Childhood Emotional Disturbances
• Daniel, Janice. …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Archives Records

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Padilla, Anne. First and Second Language Acquisition: A Comparison
• Scott, Angela. Salted and Unsalted Snacks: Taste Preferences of Second Grade Students in a Rural Area School
• Fuqua, Nancy. Acceptance by High School Students of Muffins Containing Supplemental Soy Polysaccharides
• Mans, Glee. Preference Levels of High School Freshmen for Four Cheese Food Products
• Denney, Pam. Consumer Acceptance of UHT Choclate Lowfat Milk
• Harris, Carla. Jacques-Louis David: Raphael of the Sansculottes
• Vaughn, James. Corporate Reorganization …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Archives Records

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Whicker, Garth. Agriculture and the Development of Malaysia
• McGaha. Rape, Passion, Lechery, Usury, Incest, Murder and other Matters in The Ravenger's Tragedy
• Harrison, Robert. It was a Day of Very General Awakening . . : Reformation and Revival in Russellville, Kentucky
• King, Betty. An Affirmative Decision for James's Isabel Archer
• Sutton, Joyce. Sex Bias in Performance of Women
• Logsdon, Doug. Poe's Women
• Yoder, Nate. Emily Dickinson and Her Puritan Heritage
• Davis, Aleen. Jay …

Ua35/11 Student Honors Research Bulletin, Vol. Ii, Wku Honors Program

WKU Archives Records

Articles written by honors program students. They were originally research projects, class papers or essays written for academic credit, but in each case the student has done further work editing and improving his or her manuscript for this publication. The articles represent a broad range of interests and disciplines, and they indicate a healthy attempt on the part of at least some students to dig for deeper knowledge and understanding than is usually associated with undergraduate study.

• Greene, Bruce. The Traditional Fiddle Music of South-Central Kentucky
• Moody, Marlin. Some Effects of the Herbicide Glyphosate on Johnson Grass Rhizomes
• Jones, Larry. …