Life Sciences Commons^™

A Machine Learning Framework For Identifying Molecular Biomarkers From Transcriptomic Cancer Data, Md Abdullah Al Mamun

FIU Electronic Theses and Dissertations

Cancer is a complex molecular process due to abnormal changes in the genome, such as mutation and copy number variation, and epigenetic aberrations such as dysregulations of long non-coding RNA (lncRNA). These abnormal changes are reflected in transcriptome by turning oncogenes on and tumor suppressor genes off, which are considered cancer biomarkers.

However, transcriptomic data is high dimensional, and finding the best subset of genes (features) related to causing cancer is computationally challenging and expensive. Thus, developing a feature selection framework to discover molecular biomarkers for cancer is critical.

Traditional approaches for biomarker discovery calculate the fold change for each …

Causality In Microbiomes, Md Musfiqur Rahman Sazal

FIU Electronic Theses and Dissertations

No abstract provided.

Computational Analysis Of Large-Scale Trends And Dynamics In Eukaryotic Protein Family Evolution, Joseph Boehm Ahrens

FIU Electronic Theses and Dissertations

The myriad protein-coding genes found in present-day eukaryotes arose from a combination of speciation and gene duplication events, spanning more than one billion years of evolution. Notably, as these proteins evolved, the individual residues at each site in their amino acid sequences were replaced at markedly different rates. The relationship between protein structure, protein function, and site-specific rates of amino acid replacement is a topic of ongoing research. Additionally, there is much interest in the different evolutionary constraints imposed on sequences related by speciation (orthologs) versus sequences related by gene duplication (paralogs). A principal aim of this dissertation is to …

Development Of A Methodology That Couples Satellite Remote Sensing Measurements To Spatial-Temporal Distribution Of Soil Moisture In The Vadose Zone Of The Everglades National Park, Luis G. Perez

FIU Electronic Theses and Dissertations

Spatial-temporal distribution of soil moisture in the vadose zone is an important aspect of the hydrological cycle that plays a fundamental role in water resources management, including modeling of water flow and mass transport. The vadose zone is a critical transfer and storage compartment, which controls the partitioning of energy and mass linked to surface runoff, evapotranspiration and infiltration. This dissertation focuses on integrating hydraulic characterization methods with remote sensing technologies to estimate the soil moisture distribution by modeling the spatial coverage of soil moisture in the horizontal and vertical dimensions with high temporal resolution.

The methodology consists of using …

Wildfire Assessment Using Farsite Fire Modeling: A Case Study In The Chihuahua Desert Of Mexico, John Brakeall

FIU Electronic Theses and Dissertations

The Chihuahua desert is one of the most biologically diverse ecosystems in the world, but suffers serious degradation because of changes in fire regimes resulting in large catastrophic fires. My study was conducted in the Sierra La Mojonera (SLM) natural protected area in Mexico. The purpose of this study was to implement the use of FARSITE fire modeling as a fire management tool to develop an integrated fire management plan at SLM.

Firebreaks proved to detain 100% of wildfire outbreaks. The rosetophilous scrub experienced the fastest rate of fire spread and lowland creosote bush scrub experienced the slowest rate of …