Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Short-Term Activity-Dependent Changes In Schaffer Collateral Axon Function, Benjamin Michael Owen
Short-Term Activity-Dependent Changes In Schaffer Collateral Axon Function, Benjamin Michael Owen
Theses, Dissertations and Capstones
Schaffer collaterals are the unmyelinated axons of pyramidal neurons in the CA3 area of the hippocampus, a brain structure essential for memory formation. Schaffer collateral axons conduct electrical signals in the form of action potentials from CA3 pyramidal cells to synaptic terminals in area CA1. The fidelity with which these axons conduct action potentials determines the nature of the information which can be transmitted between areas CA3 and CA1. Conduction fidelity may be affected by both normal and abnormal patterns of firing, fluctuations in ion concentration, and some drugs and toxins. In this dissertation, I examined the function of Schaffer …