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Full-Text Articles in Life Sciences
Resting State Functional Connectivity In The Default Mode Network: Relationships Between Cannabis Use, Gender, And Cognition In Adolescents And Young Adults, Megan Ritchay
Theses and Dissertations
Introduction: Cannabis is the most commonly used illicit substance in the United States, and nearly 1 in 4 young adults are current cannabis users. The psychoactive component of cannabis, THC, is active at cannabinoid receptors, type 1, or CB1 receptors. CB1 receptors play a critical role in neural development, and chronic cannabis use causes desensitization and downregulation of these receptors. Chronic cannabis use is associated with changes in resting state functional connectivity (RSFC) in the default mode network (DMN) in adolescents and young adults, although results are somewhat inconsistent across studies, likely due to differing methodologies. Additionally, cannabis effects appear …
Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward
Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward
Theses and Dissertations
The ability to effectively withhold an inappropriate response is a critical feature of cognitive control. Prior research indicates alterations in neural processes required for motor response inhibition in anxious individuals, including those with posttraumatic stress disorder (PTSD), and those who engage in regular cannabis use. However, thus far most research has examined how anxiety-related symptoms and cannabis use influence response inhibition in isolation of one another. The current study examined the interactions between anxious symptomology and recent cannabis use in a sample that recently experienced a traumatic event using functional magnetic resonance imaging (fMRI) during the completion of a Stop-Signal …
Functional Responding To Appetitive Faces Among Cannabis-Using Adolescents And Young Adults, Ryan Michael Sullivan
Functional Responding To Appetitive Faces Among Cannabis-Using Adolescents And Young Adults, Ryan Michael Sullivan
Theses and Dissertations
Cannabis use is associated with attenuated reward signaling, yet few studies have examined this relationship when viewing rewarding appetitive faces while undergoing functional neuroimaging. Furthermore, few neuroimaging analyses have examined the moderating role of gender on task-based fMRI outcomes. This study explored functional BOLD response elicited by appetitive faces while engaged in an affective go/no-go task, and specifically investigated the differences between cannabis-using and control groups, whether gender moderate findings, and brain-behavior associations. Participants (ages 16-26 years) were scanned after at least 3-weeks of monitored abstinence (cannabis-using group = 35; control group = 33). The findings demonstrated aberrant activation in …