Open Access. Powered by Scholars. Published by Universities.®
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Transplanting A Bacterial Immune System: Determining The Function Of A Novel Crispr System, Riannon Smith, Melena Garrett
Transplanting A Bacterial Immune System: Determining The Function Of A Novel Crispr System, Riannon Smith, Melena Garrett
Research on Capitol Hill
CRISPR (Clusters of Regularly Interspaced Short Palindromic Repeats) loci and cas (CRISPR-associated) genes provide adaptive immunity (see panel below) in bacteria and have recently been repurposed for genome editing.
Systems are structurally and functionally diverse.
- 2 classes, 6 types, 33 subtypes
- Very few have been studied experimentally
- None of the Type IV systems have been characterized
Potential Regulation Of Deadly Water-Borne Shigella Bacteria Pathogenesis Through The Shigella Infection Protein Spa47, Jamie Kingsford
Potential Regulation Of Deadly Water-Borne Shigella Bacteria Pathogenesis Through The Shigella Infection Protein Spa47, Jamie Kingsford
Research on Capitol Hill
- Shigella is a gram-negative, bacterial pathogen typically found in contaminated water sources.
- Each year, Shigella is responsible for over 90 million infections and 100,000 deaths stemming from symptoms of severe dysentery, fever, nausea and vomiting.
- A needle-like apparatus found on the surface of Shigella allows the bacterium to infect host cells.
- Each needle-apparatus has an associated ATPase, a protein that can hydrolyze ATP into ADP and Pi.
- The Shigella needle-apparatus ATPase Spa47 is predicted to provide the energy for infection.
- Spa47 has been shown to be essential for infection – without Spa47, no infection will occur.
- We were …