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Full-Text Articles in Life Sciences
Mycobacterium Tuberculosis Inhibitors: Action And Resistance, Pamela K. Garcia-Moreno
Mycobacterium Tuberculosis Inhibitors: Action And Resistance, Pamela K. Garcia-Moreno
FIU Electronic Theses and Dissertations
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, has been a global health problem for years. The emergence of drug resistance in this organism generates the necessity of exploring novel targets and developing new drugs. Topoisomerases are enzymes found in all kingdoms of life responsible for overcoming the topological barriers encountered during essential cellular processes. The genomes of mycobacteria encode only one type IA topoisomerase (MtopI), which has been validated as a novel TB drug target. The goal of this study is to obtain new information on the mechanism and resistance of endogenous and synthetic inhibitors of MtopI.
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Sab Concentration Determines The Chemotherapeutic Efficacy In Gynecological Cancer, Iru Paudel
Sab Concentration Determines The Chemotherapeutic Efficacy In Gynecological Cancer, Iru Paudel
FIU Electronic Theses and Dissertations
The American Cancer Society predicts there will be 110,070 new cases and 32,120 deaths due to gynecological malignancies in 2018. A major contributing factor to the high mortality associated with gynecological cancers is the recurrence of treatment-resistant tumors. Ovarian cancer (OC) remains the most lethal gynecological malignancy, yet the mechanisms responsible for regulating tumor resistance and vulnerability are largely unknown or undruggable. Therefore, the goal of this research is to identify mechanisms responsible for therapeutic resistance in gynecological cancers and discover innovative approaches to circumvent these molecular alterations. Our efforts began in OC where secondary analysis of gene expression data …