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Effect Of Shear Stress On Ecnos Expression And Dilation In Soleus Feed Arteries, Blanca Perez, Jay L. Brewster, Jeffrey Jasperse
Effect Of Shear Stress On Ecnos Expression And Dilation In Soleus Feed Arteries, Blanca Perez, Jay L. Brewster, Jeffrey Jasperse
Featured Research
Shear stress causes artery dilation and increased expression of endothelial cell nitric oxide synthase (ecNOS) in coronary and placental arteries. We sought to determine the importance of shear stress in maintaining normal dilation and normal levels of ecNOS in rat soleus feed arteries (SFA). SFA were isolated from male Sprague-Dawley rats and cannulated for in vitro microscopy (Fig. 6). SFA were exposed to no shear stress, low shear stress, or high shear stress conditions for 4 hours. After 4 hours, endothelium-dependent dilation (acetylcholine: ACh) and endothelium-independent dilation (sodium nitroprusside: SNP) were tested. Arteries were then uncannulated, mRNA was isolated, and …
Locating The Modifier Of Segregation Distorter In Drosophila Melanogaster, Samuel Craven
Locating The Modifier Of Segregation Distorter In Drosophila Melanogaster, Samuel Craven
Honors Program Projects
The Drosophila melanogaster meiotic drive system Segregation Distorter (SD) has been a topic of great interest over the past decades due to its implications for fertility issues in fruit flies and other species as well. Several genes have been associated with this system; however, little research has focused on a particular one of these genes—the Modifier of SD. The location of this modifier gene is still unknown, so multiple deleted segments of DNA that compose a suspect area along the 2nd chromosome were tested here to see if some level of distortion is established in the absence of these segments. …