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Ectopic Mineralization Of Spinal Tissues In Mice Lacking Equilibrative Nucleoside Transporter 1, Sumeeta Warraich
Ectopic Mineralization Of Spinal Tissues In Mice Lacking Equilibrative Nucleoside Transporter 1, Sumeeta Warraich
Electronic Thesis and Dissertation Repository
Equilibrative nucleoside transporter 1 (ENT1) regulates the bi-directional transfer of hydrophilic nucleosides, such as adenosine, across the plasma membrane. Mice lacking ENT1 developed calcified lesions resembling diffuse idiopathic skeletal hyperostosis (DISH) in humans. By 12 months of age, ENT1-/- mice exhibit spine stiffness, hind limb dysfunction, and paralysis. Histological examination of ENT1-/- mice revealed irregular accumulations of eosinophilic material in paraspinal ligaments and entheses, intervertebral discs, and sternocostal articulations. There was no evidence of mineralization in appendicular joints or blood vessels. Analysis of intervertebral disc tissues of 6 month old ENT1-/- and wild-type mice revealed reduced expression …
Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon
Modulation Of Synaptic Transmission By Adenosine In Layer 2/3 Of The Rat Visual Cortex In Vitro, Nicholas M. Bannon
Master's Theses
No abstract provided.