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Rapid Actions Of 1,25-Dihydroxyvitamin D3 On Phosphate Uptake In Isolated Chick Intestinal Cells, Bin Zhao
Rapid Actions Of 1,25-Dihydroxyvitamin D3 On Phosphate Uptake In Isolated Chick Intestinal Cells, Bin Zhao
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
1,25-dihydroxyvitamin D3 [1,25(OH)2D3] has been shown to promote phosphate transport rapidly in the perfused duodenal loop, relative to controls, reaching treated/av basal at T = 40 min = 1.82 ± 0.42 and 1.11 ± 0.21, respectively.
By using isolated chick enterocytes, studies were undertaken to determine whether 1,25(OH)2D3 has a direct effect on isolated intestinal cells that is manifested by either enhanced uptake or extrusion of phosphate.
In time course studies, with 4- to 8-wk-old chicks, 32P uptake in enterocytes at 10 min after addition of test substance was 0%, 130%, …