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Cacna1g Transcript Knockdown Analysis Via In Situ Hybridization, Jennifer (Shih-En) Chen
Cacna1g Transcript Knockdown Analysis Via In Situ Hybridization, Jennifer (Shih-En) Chen
Undergraduate Honors Theses
The pedunculopontine nucleus (PPN) comprises the mesencephalic locomotor region (MLR) of the midbrain. It contains glutamatergic, cholinergic, and GABAergic interneurons, but only glutamatergic neurons influence locomotion, which is our focus here. The PPN receives upstream and downstream input from the basal ganglia. It projects to the reticular formation of the brainstem, which connects to the spinal cord. The PPN is involved in a wide range of physiological and behavioral processes, but our focus is locomotion. We hypothesize that the PPN influences the reticular activating system (RAS) of the medulla and thus the central pattern generators (CPG) in the spinal cord …