Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Effect Of Shear Stress On Ecnos Expression And Dilation In Soleus Feed Arteries, Blanca Perez, Jay L. Brewster, Jeffrey Jasperse
Effect Of Shear Stress On Ecnos Expression And Dilation In Soleus Feed Arteries, Blanca Perez, Jay L. Brewster, Jeffrey Jasperse
Featured Research
Shear stress causes artery dilation and increased expression of endothelial cell nitric oxide synthase (ecNOS) in coronary and placental arteries. We sought to determine the importance of shear stress in maintaining normal dilation and normal levels of ecNOS in rat soleus feed arteries (SFA). SFA were isolated from male Sprague-Dawley rats and cannulated for in vitro microscopy (Fig. 6). SFA were exposed to no shear stress, low shear stress, or high shear stress conditions for 4 hours. After 4 hours, endothelium-dependent dilation (acetylcholine: ACh) and endothelium-independent dilation (sodium nitroprusside: SNP) were tested. Arteries were then uncannulated, mRNA was isolated, and …