Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Mechanisms Of Calcium Wave Initiation And Propagation In Astrocytes, Charles Emmet Stout
Mechanisms Of Calcium Wave Initiation And Propagation In Astrocytes, Charles Emmet Stout
Loma Linda University Electronic Theses, Dissertations & Projects
Glial cells display propagated waves of cytoplasmic calcium (Ca2+) mobilization that spread outward from an initiating cell to involve hundreds to thousands of surrounding cells. This intercellular communication system is thought to initiate and coordinate Ca2+ dependent processes associated with vascular control, gut motility, uterine contraction, and synaptic plasticity. Not surprisingly, aberrant Ca signaling is thought to play a featured role in the pathophysiologies associated with dysfunction of these processes. This suggests that elucidation of the mechanism of Ca2+ waves will lead to rational therapeutic modalities for a variety of clinically significant entities.
Early studies revealed …