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Microrna Cargo Of Extracellular Vesicles From Alcohol-Exposed Monocytes Signals Naive Monocytes To Differentiate Into M2 Macrophages, Banishree Saha, Fatemeh Momen-Heravi, Karen Kodys, Gyongyi Szabo
Microrna Cargo Of Extracellular Vesicles From Alcohol-Exposed Monocytes Signals Naive Monocytes To Differentiate Into M2 Macrophages, Banishree Saha, Fatemeh Momen-Heravi, Karen Kodys, Gyongyi Szabo
Gyongyi Szabo
Membrane-coated extracellular vesicles (EVs) released by cells can serve as vehicles for delivery of biological materials and signals. Recently, we demonstrated that alcohol-treated hepatocytes cross-talk with immune cells via exosomes containing microRNA (miRNAs). Here, we hypothesized that alcohol-exposed monocytes can communicate with naive monocytes via EVs. We observed increased numbers of EVs, mostly exosomes, secreted by primary human monocytes and THP-1 monocytic cells in the presence of alcohol in a concentration- and time-dependent manner. EVs derived from alcohol-treated monocytes stimulated naive monocytes to polarize into M2 macrophages as indicated by increased surface expression of CD68 (macrophage marker), M2 markers (CD206 …
Myotonia Congenita, Christoph Lossin, Alfred George
Myotonia Congenita, Christoph Lossin, Alfred George
Christoph Lossin, Ph.D.
Myotonia is a symptom of many different acquired and genetic muscular conditions that impair the relaxation phase of muscular contraction. Myotonia congenital is a specific inherited disorder of muscle membrane hyperexcitability caused by reduced sarcolemmal chloride conductance due to mutations invCLCN1, the gene coding for the main skeletal muscle chloride channel ClC-1.The disorder may be transmitted as either an autosomal-dominant or recessive trait with close to 130 currently known mutations. Although this is a rare disorder, elucidation of the pathophysiology underlying myotonia congenital established the importance of sarcolemmal chloride conductance in the control of muscle excitability and demonstrated the first …
The Effect Of Water And Nitrogen On The Response Of Sorghum Cultivars With Contrasting Nitrogen Use Efficiency, Teshome Regassa
The Effect Of Water And Nitrogen On The Response Of Sorghum Cultivars With Contrasting Nitrogen Use Efficiency, Teshome Regassa
Teshome H. Regassa
Water and nitrogen (N) are important environmental factors limiting sorghum production. Information is lacking on the combined effects of water and N for cultivars with different degrees of water and/or N stress tolerance. Sorghum cultivars known for N and water stress tolerance difference were evaluated to identify plant characteristics contributing to N use efficiency (NUE). Cultivars San Chi San and CK-60 were evaluated at Mead, NE on a Sharpsburg silty clay loam soil under water (stress and non-stress), and N (0, 40, 80, and 120 kg ha−1) rates. Experimental units were arranged in split-split plot and treatments were …