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Dietary Selenium Deficiency Exacerbates Dss-Induced Epithelial Injury And Aom/Dss-Induced Tumorigenesis., C. W. Barrett, K. Singh, A. K. Motley, M. K. Lintel, E. Matafonova, A. M. Bradley, W. Ning, Shenika Poindexter Toliver
Dietary Selenium Deficiency Exacerbates Dss-Induced Epithelial Injury And Aom/Dss-Induced Tumorigenesis., C. W. Barrett, K. Singh, A. K. Motley, M. K. Lintel, E. Matafonova, A. M. Bradley, W. Ning, Shenika Poindexter Toliver
Faculty and Staff Publications
Selenium (Se) is an essential micronutrient that exerts its functions via selenoproteins. Little is known about the role of Se in inflammatory bowel disease (IBD). Epidemiological studies have inversely correlated nutritional Se status with IBD severity and colon cancer risk. Moreover, molecular studies have revealed that Se deficiency activates WNT signaling, a pathway essential to intestinal stem cell programs and pivotal to injury recovery processes in IBD that is also activated in inflammatory neoplastic transformation. In order to better understand the role of Se in epithelial injury and tumorigenesis resulting from inflammatory stimuli, we examined colonic phenotypes in Se-deficient or …