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Brca1 Dna-Binding Activity Is Stimulated By Bard1, Amanda Simons, Andrew Horwitz, Lea Starita, Karen Griffin, R Williams, J.N. Glover, Jeffrey Parvin
Brca1 Dna-Binding Activity Is Stimulated By Bard1, Amanda Simons, Andrew Horwitz, Lea Starita, Karen Griffin, R Williams, J.N. Glover, Jeffrey Parvin
Amanda Simons
The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous cellular processes, including transcription, ubiquitination, and DNA repair. Its tumor suppression activity is tightly linked to that of BARD1, a protein that heterodimerizes with BRCA1. It has been previously shown that BRCA1 binds to DNA, an interesting functional observation in light of the genetic data linking BRCA1 to DNA repair pathways. In this work, we reexamine the DNA-binding properties of BRCA1, comparing them with the DNA-binding properties of the BRCA1/BARD1 heterodimer. Because nuclear BRCA1 exists as a heterodimer with BARD1, it is likely that in vitro studies of …