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Full-Text Articles in Life Sciences
Host Pathogen Interactions: Is Arabidopsis Thaliana Remembered By Its Nemesis Pseudomonas Syringae?, Daniel Z. Kreiser
Host Pathogen Interactions: Is Arabidopsis Thaliana Remembered By Its Nemesis Pseudomonas Syringae?, Daniel Z. Kreiser
Lawrence University Honors Projects
Plants contain innate immune systems that deter pathogen infection. Pattern recognition receptors bind microbe-associated molecular patterns (MAMPs), triggering immunity. MAMPs are proteins exclusive to pathogens that are typically indispensable for their survival. For this reason, MAMPs cannot be mutated or removed without causing pathogen death. However, this does not necessitate constitutive expression of MAMPs. In this study, the MAMP response of Arabidopsis thaliana was utilized to determine differential detection of MAMPs expressed by Pseudomonas syringe pv. tomato DC3000 when pretreated with A. thaliana. Results demonstrated that more MAMPs are detected when P. syringae had previously encountered A. thaliana, …
Novel Phenol Soluble Modulin Derivatives In Community-Associated Methicillin- Resistant Staphylococcus Aureus Identified Through Imaging Mass Spectrometry., D. Gonzalez, Cheryl Okumura, A. Hollands, R. Kersten, K. Akong-Moore, M. Pence, C. Malone, J. Derieux, B. Moore, A. Horswill, J. Dixon, P. Dorrestein, V. Nizet
Novel Phenol Soluble Modulin Derivatives In Community-Associated Methicillin- Resistant Staphylococcus Aureus Identified Through Imaging Mass Spectrometry., D. Gonzalez, Cheryl Okumura, A. Hollands, R. Kersten, K. Akong-Moore, M. Pence, C. Malone, J. Derieux, B. Moore, A. Horswill, J. Dixon, P. Dorrestein, V. Nizet
Cheryl Okumura
Staphylococcus aureus causes a wide range of human disease ranging from localized skin and soft tissue infections to potentially lethal systemic infections. S. aureus has the biosynthetic ability to generate numerous virulence factors that assist in circumventing the innate immune system during disease pathogenesis. Recent studies have uncovered a set of extracellular peptides produced by community-associated methicillin-resistant S. aureus (CA-MRSA) with homology to the phenol-soluble modulins (PSMs) from Staphylococcus epidermidis. CA-MRSA PSMs contribute to skin infection and recruit and lyse neutrophils, and truncated versions of these peptides possess antimicrobial activity. In this study, novel CA-MRSA PSM derivatives were discovered by …