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Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Unusual Structure Of A Human Middle Repetitive Dna, Duminda D. Ratnasinghe
Unusual Structure Of A Human Middle Repetitive Dna, Duminda D. Ratnasinghe
Electronic Theses and Dissertations
The L2Hs sequences are a polymorphic, interspersed, middle repetitive DNA family unique to human genomes. Genomic fingerprinting indicates that these DNAs vary from one individual to another and between tissues of the same individual. Sequence analysis reveals that they are AT-rich (76%) and contain many unusual sequence arrangements (palindromes, inverted and direct repeats). These sequence properties confer on the L2Hs elements the potential to fold into non-B-form structures, a characteristic of recombination hot spots. To test this hypothesis carbodiimide, osmium tetroxide and S$\sb1$ nuclease were used as single-strand specific probes to study a recombinant plasmid, pN6.4.39, containing a single L2Hs …
Inhibition Of Cytochrome P-450 But Not Neutrophil Depletion Prevents The Pulmonary Toxicity Associated With 1-Nitronaphthalene, Steven Michael Green
Inhibition Of Cytochrome P-450 But Not Neutrophil Depletion Prevents The Pulmonary Toxicity Associated With 1-Nitronaphthalene, Steven Michael Green
Masters Theses
1-Nitronaphthalene (1-NN) is an environmental contaminant that has been shown to cause pulmonary toxicity in rodents. To examine the contribution of cytochrome P-450 to the metabolism and subsequent toxicity of 1-NN, rats were pretreated with chloramphenicol, a suicide substrate of P-450. To determine if inflammation plays a role in 1-NN toxicity, rats were pretreated with cyclophosphamide to deplete neutrophils. In both experiments, morphological analysis of the lower airways was performed with light and electron microscopy. A second group of animals was examined for biochemical indicators of inflammation and cell damage. The parameters examined were cell content, protein content and lactate …
The Isolation And Identification Of Polyphenolics From Grape Seeds And Their Activity Towards Specific Cell Lines, Joseph A. Reddy
The Isolation And Identification Of Polyphenolics From Grape Seeds And Their Activity Towards Specific Cell Lines, Joseph A. Reddy
Chemistry & Biochemistry Theses & Dissertations
Grape seed extract is being marketed in France for cardiovascular use and skin care. The active constituents of both these drugs are certain polyphenols called procyanidins. A similar seed extract has now been obtained from Virginia Chardonnay grape seeds. Ten of the major components in this extract have been isolated in their pure form by the semi-preparative HPLC separation on a YMC ODS-AQ (Octadecylsilane-AQ) column. The ODS-Aq column has been shown to have a better resolving capacity compared to the Spherisorb ODS (Octadecylsilane) column previously described in the literature. This has been attributed to the ODSAQ support which has both …
The Cytotoxic Effect Of Tropical Plants On Human And Rat Hepatoma Cells, Mark Tafazoli
The Cytotoxic Effect Of Tropical Plants On Human And Rat Hepatoma Cells, Mark Tafazoli
Honors Capstone Projects and Theses
No abstract provided.
Analysis Of The Proteoglycan Content In Fresh And Cryopreserved Porcine Cardiovascular Tissues, Yun Hee Shon
Analysis Of The Proteoglycan Content In Fresh And Cryopreserved Porcine Cardiovascular Tissues, Yun Hee Shon
Theses and Dissertations in Biomedical Sciences
The purpose of this research was to study the effects of cryopreservation on the proteoglycan (PG) and mineral content of aorta conduit tissue. Proteoglycans from fresh and cryopreserved porcine aorta conduit tissues were isolated by extraction with 4 M guanidine (Gdn) - hydrochloride (HCl) for 48 hours. Quantitative analysis of extracted proteoglycans revealed that the content of proteoglycan material from cryopreserved tissue, measured as uronate and protein per unit weight of wet tissue, was similar to that from fresh tissue. Gel permeation column chromatography studies suggested that proteoglycans present in three CsCl fractions from cryopreserved tissues had molecular weights similar …
Chronic Estrogen-Induced Alterations In Adrenocorticotropin And Corticosterone Secretion: Relationship To Mineralocorticoid And Glucocorticoid Receptor Regulation In The Female Rat Anterior Pituitary Gland And Brain, Loyd H. Burgess
Dissertations
No abstract provided.
Burden In Spousal Caregivers: A Correlational Study Of The Effect And Interaction Of Stressors, Vulnerability, Psychological Resources And Social Supports On The Development Of Burden In Spousal Caregivers Of The Chronically Ill, Sheila Marie Crossen-Powell
Burden In Spousal Caregivers: A Correlational Study Of The Effect And Interaction Of Stressors, Vulnerability, Psychological Resources And Social Supports On The Development Of Burden In Spousal Caregivers Of The Chronically Ill, Sheila Marie Crossen-Powell
Dissertations, Theses, and Masters Projects
This study investigated burden in a convenience, nonrandom sample of 120 spousal caregivers of cardiac patients, who resided at home in the Richmond, VA area, had health insurance, and received medical care from private providers. Using Vitaliano's theory that burden is a function of stressors and personal vulnerability moderated by psychological resources and social supports, the study examined the relationships between those five constructs.;Burden was measured by the Brief Symptom Inventory and Montgomery's Scales of Objective and Subjective Burden. The Hassles and Uplifts Scales was used to measure stressors; demographic data and the Self control, Responsibility, Socialization, Psychological Mindedness, Tolerance, …
The Effects Of Teratogens On Serotonin Expression In Drosophila Embryonic Cell Cultures, Keri Joel Hopkins
The Effects Of Teratogens On Serotonin Expression In Drosophila Embryonic Cell Cultures, Keri Joel Hopkins
Theses Digitization Project
No abstract provided.
Cervical Cancer: A Retrospective Study Of The Dna Ploidy Status Using Flow Cytometry And Its Prognostic Applications, Omar Roberto Fagoaga
Cervical Cancer: A Retrospective Study Of The Dna Ploidy Status Using Flow Cytometry And Its Prognostic Applications, Omar Roberto Fagoaga
Theses Digitization Project
No abstract provided.
Characterization Of Early B Lymphocyte Activation During Trichinella Spiralis Infection In Rats, Elizabeth Margaret Richards
Characterization Of Early B Lymphocyte Activation During Trichinella Spiralis Infection In Rats, Elizabeth Margaret Richards
Theses Digitization Project
No abstract provided.
The Relationships Between Retrospective Perceptions Of An Alcoholic Home Environment With Levels Of Differentiation Of Self And Trait Anxiety In Adult Children Of Alcoholics, Barbara Lynn Rojas-Hughes
The Relationships Between Retrospective Perceptions Of An Alcoholic Home Environment With Levels Of Differentiation Of Self And Trait Anxiety In Adult Children Of Alcoholics, Barbara Lynn Rojas-Hughes
Dissertations, Theses, and Masters Projects
The purpose of this study was to investigate the relationships between adult children of alcoholics (ACOA's) recollections of their family of origin home environments, with present day levels of ACOA differentiation of self, and trait anxiety. The author explored the influence of ACOA gender differences and a variety of demographic information.;The ACOA volunteers for this study were recruited from The College of William and Mary in Virginia. to be included in the study, subjects must have met the following criteria: (a) the volunteer's age must have been 18 years or above; (b) subjects met the ACOA criteria by scoring a …
Ultrastructure And Mitosis Of Glaucosphaera Vacuolata, Steven Philip Allan Goss
Ultrastructure And Mitosis Of Glaucosphaera Vacuolata, Steven Philip Allan Goss
Dissertations, Theses, and Masters Projects
No abstract provided.